Published 6 issues per year
ISSN Print: 1045-4403
ISSN Online: 2162-6502
Indexed in
Association Between TLR4 Polymorphism and Periodontitis Susceptibility: A Meta-Analysis
ABSTRACT
TLR4 has been implicated in periodontal disease, but the association between the TLR4 Asp299Gly and Thr399Ile polymorphisms and the risk of periodontal disease remains unclear. Therefore, the aim of this study was to investigate the association between the TLR4 Asp299Gly and Thr399Ile polymorphism and periodontal disease. A search of electronic databases identified previous studies evaluating the association of the polymorphisms of TLR4 and periodontitis risk. The association was evaluated by odds ratio (OR) and its 95% confidence interval (CI). The results showed that TLR4 Asp299Gly and Thr399Ile were not associated with a significant risk of periodontitis (OR = 0.96, 95% CI = 0.80−1.16 for G versus A; OR = 1.39, 95% CI = 0.82−2.36 for AG/GG versus AA; OR = 1.05, 95% CI = 0.52−2.15 for T versus C; OR = 0.76, 95% CI = 0.55−1.04 for CT/TT versus CC). In the stratified analyses, there was no significantly increased risk for the studies of chronic periodontitis and aggressive periodontitis. Our meta-analysis revealed that the two common TLR4 polymorphisms, Asp299Gly and Thr399Ile, have no association with the likelihood of periodontitis. In a subgroup analysis by ethnicity and periodontitis type, the results also did not show any association. However, there was a significant increased risk for periodontitis in recessive models of Asp299Gly. The effect of genetic networks and their mutual interactions in the TLR4 signaling pathway on periodontitis susceptibility needs further study.
-
Han Min-xuan, Ding Cheng, Kyung Hee-Moon, Genetic polymorphisms in pattern recognition receptors and risk of periodontitis: Evidence based on 12,793 subjects, Human Immunology, 76, 7, 2015. Crossref
-
Jin Su-Han, Guan Xiao-Yan, Liang Wen-Hong, Bai Guo-Hui, Liu Jian-Guo, TLR4 polymorphism and periodontitis susceptibility, Medicine, 95, 36, 2016. Crossref
-
Wei Xue-Mei, Chen Yong-Ji, Wu Lan, Cui Li-Jun, Hu Ding-Wei, Zeng Xian-Tao, Tumor necrosis factor-α G-308A (rs1800629) polymorphism and aggressive periodontitis susceptibility: a meta-analysis of 16 case-control studies, Scientific Reports, 6, 1, 2016. Crossref
-
Gonçalves-Anjo Nuno, Leite-Pinheiro Fátima, Cortinhas António, Bento Teresa, Leitão José Carlos, Dias Isabel, Viegas Carlos, Bastos Estela, Lack of association between the toll-like receptor 4 gene c.896A > G polymorphism and the predisposition to periodontal disease: An updated systematic review and meta-analysis, Meta Gene, 18, 2018. Crossref
-
Zacarias Joana Maira Valentini, de Alencar Josiane Bazzo, Tsuneto Patrícia Yumeko, Souza Victor Hugo de, Silva Cléverson O., Visentainer Jeane Eliete Laguila, Sell Ana Maria, The Influence of TLR4, CD14, OPG, and RANKL Polymorphisms in Periodontitis: A Case-Control Study, Mediators of Inflammation, 2019, 2019. Crossref