Library Subscription: Guest
Critical Reviews™ in Eukaryotic Gene Expression

Published 6 issues per year

ISSN Print: 1045-4403

ISSN Online: 2162-6502

The Impact Factor measures the average number of citations received in a particular year by papers published in the journal during the two preceding years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) IF: 1.6 To calculate the five year Impact Factor, citations are counted in 2017 to the previous five years and divided by the source items published in the previous five years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) 5-Year IF: 2.2 The Immediacy Index is the average number of times an article is cited in the year it is published. The journal Immediacy Index indicates how quickly articles in a journal are cited. Immediacy Index: 0.3 The Eigenfactor score, developed by Jevin West and Carl Bergstrom at the University of Washington, is a rating of the total importance of a scientific journal. Journals are rated according to the number of incoming citations, with citations from highly ranked journals weighted to make a larger contribution to the eigenfactor than those from poorly ranked journals. Eigenfactor: 0.00058 The Journal Citation Indicator (JCI) is a single measurement of the field-normalized citation impact of journals in the Web of Science Core Collection across disciplines. The key words here are that the metric is normalized and cross-disciplinary. JCI: 0.33 SJR: 0.345 SNIP: 0.46 CiteScore™:: 2.5 H-Index: 67

Indexed in

Knockdown of ECHS1 Protein Expression Inhibits Hepatocellular Carcinoma Cell Proliferation via Suppression of Akt Activity

Volume 23, Issue 3, 2013, pp. 275-282
DOI: 10.1615/CritRevEukaryotGeneExpr.2013007531
Get accessGet access

ABSTRACT

Overexpression of ECHS1 occurs in different cancers, including hepatocellular carcinoma (HCC). ECHS1 is also reported to have an oncogenic activity in various human cancers. This study investigated the effect of ECHS1 knockdown on the regulation of HCC growth. ECHS1 shRNA suppressed the expression of ECHS1 protein in HepG2 cells compared to the negative control vector-transfected HCC cells. ECHS1 knockdown also reduced HCC cell viability and enhanced cisplatin-induced apoptosis in HCC cells. Akt activation and the expression of various cell cycle-related genes were inhibited following ECHS1 knockdown. ECHS1 shRNA suppressed hepatocellular carcinoma growth in tumor xenograft mice. These data demonstrate that ECHS1 may play a role in HCC progression, suggesting that inhibition of ECHS1 expression using ECHS1 shRNA should be further evaluated as a novel target for the control of HCC.

CITED BY
  1. Veres Daniel V., Gyurkó Dávid M., Thaler Benedek, Szalay Kristóf Z., Fazekas Dávid, Korcsmáros Tamás, Csermely Peter, ComPPI: a cellular compartment-specific database for protein–protein interaction network analysis, Nucleic Acids Research, 43, D1, 2015. Crossref

  2. Zhu Xiao-San, Gao Peng, Dai Yi-Chen, Xie Jun-Pei, Zeng Wei, Lian Qing-Na, Attenuation of enoyl coenzyme A hydratase short chain 1 expression in gastric cancer cells inhibits cell proliferation and migration in vitro, Cellular and Molecular Biology Letters, 19, 4, 2014. Crossref

  3. Yashin Anatoliy I., Wu Deqing, Arbeeva Liubov S., Arbeev Konstantin G., Kulminski Alexander M., Akushevich Igor, Kovtun Mikhail, Culminskaya Irina, Stallard Eric, Li Miaozhu, Ukraintseva Svetlana V., Genetics of aging, health, and survival: dynamic regulation of human longevity related traits, Frontiers in Genetics, 6, 2015. Crossref

  4. Shi Yafei, Qiu Min, Wu Yanyan, Hai Lu, MiR-548-3p functions as an anti-oncogenic regulator in breast cancer, Biomedicine & Pharmacotherapy, 75, 2015. Crossref

  5. LIN BI-YUN, XIAO CHUAN-XING, ZHAO WEN-XIU, XIAO LI, CHEN XU, LI PING, WANG XIAO-MIN, Enoyl-coenzyme A hydratase short chain 1 silencing attenuates the proliferation of hepatocellular carcinoma by inhibiting epidermal growth factor signaling in vitro and in vivo, Molecular Medicine Reports, 12, 1, 2015. Crossref

  6. ZHAO QING-MEI, KUANG FEI, WU HAN, ZHANG YU-HAO, Attenuation of enoyl coenzyme A hydratase 1 expression in colorectal cancer cells using small interfering RNA inhibits cell proliferation and migration, Molecular Medicine Reports, 12, 1, 2015. Crossref

  7. XIE JUN-PEI, ZHU XIAO-SAN, DAI YI-CHEN, YU CUI, XIE TAO, CHEN ZHANG-XING, Expression of enoyl coenzyme A hydratase, short chain, 1, in colorectal cancer and its association with clinicopathological characteristics, Molecular and Clinical Oncology, 2, 6, 2014. Crossref

  8. Sehrawat Urmila, Pokhriyal Ruchika, Gupta Ashish Kumar, Hariprasad Roopa, Khan Mohd Imran, Gupta Divya, Naru Jasmine, Singh Sundararajan Baskar, Mohanty Ashok Kumar, Vanamail Perumal, Kumar Lalit, Kumar Sunesh, Hariprasad Gururao, Comparative Proteomic Analysis of Advanced Ovarian Cancer Tissue to Identify Potential Biomarkers of Responders and Nonresponders to First-Line Chemotherapy of Carboplatin and Paclitaxel, Biomarkers in Cancer, 8, 2016. Crossref

  9. Liu Fangfeng, Li Hongguang, Chang Hong, Wang Jianlu, Lu Jun, Identification of Hepatocellular Carcinoma-associated Hub Genes and Pathways by Integrated Microarray Analysis, Tumori Journal, 101, 2, 2015. Crossref

  10. CHEN ZHANGXING, ZHU XIAOSAN, XIE TAO, XIE JUNPEI, QUO KONG, LIU XIANG, Drug resistance reversed by silencing LIM domain-containing protein 1 expression in colorectal carcinoma, Oncology Letters, 8, 2, 2014. Crossref

  11. Pokhriyal Ruchika, Hariprasad Roopa, Kumar Lalit, Hariprasad Gururao, Chemotherapy Resistance in Advanced Ovarian Cancer Patients, Biomarkers in Cancer, 11, 2019. Crossref

  12. Li Rui, Hao Yanyu, Wang Qiuhan, Meng Yuan, Wu Kunhe, Liu Chaoqun, Xu Lijun, Liu Ziguang, Zhao Liang, ECHS1, an interacting protein of LASP1, induces sphingolipid-metabolism imbalance to promote colorectal cancer progression by regulating ceramide glycosylation, Cell Death & Disease, 12, 10, 2021. Crossref

  13. Vastrad Basavaraj, Vastrad Chanabasayya, Screening and identification of potential prognostic biomarkers in bladder urothelial carcinoma: Evidence from bioinformatics analysis, Gene Reports, 20, 2020. Crossref

  14. Yang Yuting, Zhang Yun, Yang Changcheng, Fang Fang, Wang Ying, Chang Haiyan, Chen Ze, Chen Ping, Differential mitochondrial proteomic analysis of A549 cells infected with avian influenza virus subtypes H5 and H9, Virology Journal, 18, 1, 2021. Crossref

  15. Dalhat Mahmood Hassan, Mohammed Mohammed Razeeth Shait, Ahmad Abrar, Khan Mohammad Imran, Choudhry Hani, Remodelin, a N‐acetyltransferase 10 (NAT10) inhibitor, alters mitochondrial lipid metabolism in cancer cells, Journal of Cellular Biochemistry, 122, 12, 2021. Crossref

  16. Burgin Harrison, Sharpe Alice J., Nie Shuai, Ziemann Mark, Crameri Jordan J., Stojanovski Diana, Pitt James, Ohtake Akira, Murayama Kei, McKenzie Matthew, Loss of mitochondrial fatty acid β‐oxidation protein short‐chain Enoyl‐CoA hydratase disrupts oxidative phosphorylation protein complex stability and function , The FEBS Journal, 2022. Crossref

Begell Digital Portal Begell Digital Library eBooks Journals References & Proceedings Research Collections Prices and Subscription Policies Begell House Contact Us Language English 中文 Русский Português German French Spain