Library Subscription: Guest
Begell Digital Portal Begell Digital Library eBooks Journals References & Proceedings Research Collections
Critical Reviews™ in Eukaryotic Gene Expression
IF: 2.156 5-Year IF: 2.255 SJR: 0.649 SNIP: 0.599 CiteScore™: 3

ISSN Print: 1045-4403
ISSN Online: 2162-6502

Critical Reviews™ in Eukaryotic Gene Expression

DOI: 10.1615/CritRevEukarGeneExpr.v17.i2.40
pages 149-158

Responsiveness of Osteoblastic and Osteolytic Bone Metastases to Vitamin D Analogs

Sara Peleg
Department of Endocrine Neoplasia and Hormonal Disorders, The University of Texas, M. D. Anderson Cancer Center, Houston, TX

ABSTRACT

Bone is the primary site of metastases in advanced androgen-independent prostate cancer. These metastases are primarily bone-forming, although the presence of osteolytic response has also been reported. Bone-homing therapy is a strategy based on the popular seed-and-soil relationship between the epithelial malignant cells and the bone stroma. Calcitriol (1,25-dihydroxyvitamin D3) and its synthetic analogs (deltanoids) are drugs that have a direct effect on both the skeleton and the invading metastatic cells and, therefore, are considered useful in the treatment of advanced prostate cancer. In this article, I review the nature of the response induced by the malignant cells in the bone (bone formation or bone resorption) and how it affects the outcome of a vitamin D analog treatment in preclinical models of metastatic bone disease.


Articles with similar content:

Molecular Mechanisms of Tumor-Bone Interactions in Osteolytic Metastases
Critical Reviews™ in Eukaryotic Gene Expression, Vol.10, 2000, issue 2
Theresa A. Guise, John M. Chirgwin
The CD44 Adhesion Molecule and Metastasis
Critical Reviews™ in Oncogenesis, Vol.5, 1994, issue 2-3
Kenneth K. Tanabe, Hideyuki Saya
Does TNF Promote or Restrain Osteoclastogenesis and Inflammatory Bone Resorption?
Critical Reviews™ in Immunology, Vol.38, 2018, issue 4
Baohong Zhao
Cell Fusion in Myeloma Marrow Microenvironment: Role in Tumor Progression
Critical Reviews™ in Oncogenesis, Vol.18, 2013, issue 1-2
Franco Dammacco, Franco Silvestris, Mauro Cives, Sabino Ciavarella
Cell Membrane-Associated MT1-MMP-Dependent Activation of Pro-MMP-2 in A375 Melanoma Cells
Journal of Environmental Pathology, Toxicology and Oncology, Vol.24, 2005, issue 1
Amitava Chatterjee, Jayati Chakrabarti, Aparna Mitra, Aniruddha Banerji