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Critical Reviews™ in Eukaryotic Gene Expression

Published 6 issues per year

ISSN Print: 1045-4403

ISSN Online: 2162-6502

The Impact Factor measures the average number of citations received in a particular year by papers published in the journal during the two preceding years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) IF: 1.6 To calculate the five year Impact Factor, citations are counted in 2017 to the previous five years and divided by the source items published in the previous five years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) 5-Year IF: 2.2 The Immediacy Index is the average number of times an article is cited in the year it is published. The journal Immediacy Index indicates how quickly articles in a journal are cited. Immediacy Index: 0.3 The Eigenfactor score, developed by Jevin West and Carl Bergstrom at the University of Washington, is a rating of the total importance of a scientific journal. Journals are rated according to the number of incoming citations, with citations from highly ranked journals weighted to make a larger contribution to the eigenfactor than those from poorly ranked journals. Eigenfactor: 0.00058 The Journal Citation Indicator (JCI) is a single measurement of the field-normalized citation impact of journals in the Web of Science Core Collection across disciplines. The key words here are that the metric is normalized and cross-disciplinary. JCI: 0.33 SJR: 0.345 SNIP: 0.46 CiteScore™:: 2.5 H-Index: 67

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Vitamin D Modulation of the Activity of Estrogenic Compounds in Bone Cells In Vitro and In Vivo

Volume 17, Issue 2, 2007, pp. 115-148
DOI: 10.1615/CritRevEukarGeneExpr.v17.i2.30
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ABSTRACT

Vitamin D analogs modulate different organs, including modulation of energy metabolism, through the induction of creatine kinase (CK) activity. Skeletal organs from vitamin D-depleted rats showed lower constituent CK than those from vitamin D-replete rats. Moreover, estradiol-17β (E2) or dihydrotestosterone (DHT), which increased CK in organs from intact female or male rats, respectively, stimulated much less CK in vitamin D-depleted rats. Treatment of intact female rats with noncalcemic vitamin D analogs significantly upregulated E2- and DHT-induced CKresponse. These analogs upregulated the CK response to selective estrogen receptor modulators (SERMs) in organs from intact or ovariectomized (Ovx) female rats but abolished SERMs' inhibitory effect on E2-induced CK. These analogs significantly increased estradiol receptor α (ERα) protein in skeletal organs as well as histomorphological and biochemical changes due to this treatment followed by E2 or DHT. The analogs alone markedly altered the growth plate and the trabeculae and increased trabecular bone volume (%TB V) and trabecular width. The addition of E2 or DHT to this treatment restored all parameters as well as increased %TBV and cell proliferation. Treatment of Ovx female rats with JK 1624 F2-2 (JKF) decreased growth-plate width and increased %TB V, whereas QW1624 F2-2 (QW) restored growth-plate width and %TB V. Treatment of E2 with JKF restored %TBV and growth-plate width, whereas E2 with QW restored all parameters, including cortical width. There was also upregulation of the response of CK to E2 in both combined treatments. Our human-derived osteoblast (hObs)-like cell cultures respond to estrogenic compounds, and pretreating them with JKF upregulated the CK response to E2, raloxifene (Ral), and some phytoestrogens. ERα and ERβ proteins, as well as mRNA, were modulated by CB 1093 (CB) and JKF. JKF increased specific nuclear E2 binding in female hObs but inhibited specific membranal E2 binding. hObs express 25 hydroxyvitamin D3-1α hydroxylase (1-OHase)-mRNA and its biological activity, which are both modulated by parathyroid hormone (PTH) and estrogenic compounds. Our results demonstrate mutual interaction between vitamin D and estrogenic compounds. We therefore conclude that combined treatment with less-calcemic analogs of vitamin D and estrogenic compounds might be superior for treatment of bone damage caused by ovariectomy in female rats, with possible application for postmenopausal osteoporosis.

CITED BY
  1. Somjen D., Grafi-Cohen M., Posner G.H., Sharon O., Kraiem Z., Stern N., Vitamin D less-calcemic analog modulates the expression of estrogen receptors, vitamin D receptor and 1α-hydroxylase 25-hydroxy vitamin D in human thyroid cancer cell lines, The Journal of Steroid Biochemistry and Molecular Biology, 136, 2013. Crossref

  2. Barton Matthias, Position paper: The membrane estrogen receptor GPER – Clues and questions, Steroids, 77, 10, 2012. Crossref

  3. Somjen D., Kulesza U., Sharon O., Knoll E., Stern N., New vitamin D less-calcemic analog affect human bone cell line and cultured vascular smooth muscle cells similar to other less-calcemic analogs, The Journal of Steroid Biochemistry and Molecular Biology, 140, 2014. Crossref

  4. Fu Lingjie, Tang Tingting, Miao Yanying, Hao Yongqiang, Dai Kerong, Effect of 1,25-dihydroxy vitamin D3 on fracture healing and bone remodeling in ovariectomized rat femora, Bone, 44, 5, 2009. Crossref

  5. Elnenaei Manal O., Chandra Rama, Mangion Tina, Moniz Caje, Genomic and metabolomic patterns segregate with responses to calcium and vitamin D supplementation, British Journal of Nutrition, 105, 1, 2011. Crossref

  6. Somjen D., Katzburg S., Kohen F., Gayer B., Posner G. H., Yoles I., Livne E., The effects of native and synthetic estrogenic compounds as well as vitamin D less-calcemic analogs on adipocytes content in rat bone marrow, Journal of Endocrinological Investigation, 34, 2, 2011. Crossref

  7. Kesby James P., Cui Xiaoying, Ko Pauline, McGrath John J., Burne Thomas H.J., Eyles Darryl W., Developmental vitamin D deficiency alters dopamine turnover in neonatal rat forebrain, Neuroscience Letters, 461, 2, 2009. Crossref

  8. Cekic Milos, Sayeed Iqbal, Stein Donald G., Combination treatment with progesterone and vitamin D hormone may be more effective than monotherapy for nervous system injury and disease, Frontiers in Neuroendocrinology, 30, 2, 2009. Crossref

  9. Ryan Jackson W., Starczak Yolandi, Tsangari Helen, Sawyer Rebecca K., Davey Rachel A., Atkins Gerald J., Morris Howard A., Anderson Paul H., Sex-related differences in the skeletal phenotype of aged vitamin D receptor global knockout mice, The Journal of Steroid Biochemistry and Molecular Biology, 164, 2016. Crossref

  10. Park Juwon, Bae Eun Jin, Lee Taeck-hyun, Jin Woo Sung, Choi Hyunhee, Yang Jeong Sook, Hong Ji Eun, Ferritin and hemoglobin level of korean according to vitamin D state: The Korean National Health and Nutrition Examination Survey IV, V (2008~2012), Journal of the Korea Academia-Industrial cooperation Society, 17, 9, 2016. Crossref

  11. Dai S.Q., Yu L.P., Shi X., Wu H., Shao P., Yin G.Y., Wei Y.Z., Serotonin regulates osteoblast proliferation and function in vitro, Brazilian Journal of Medical and Biological Research, 47, 9, 2014. Crossref

  12. Hussain S.M., Daly R.M., Wang Y., Shaw J.E., Magliano D.J., Graves S., Ebeling P.R., Wluka A.E., Cicuttini F.M., Association between serum concentration of 25-hydroxyvitamin D and the risk of hip arthroplasty for osteoarthritis: result from a prospective cohort study, Osteoarthritis and Cartilage, 23, 12, 2015. Crossref

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