Library Subscription: Guest
Critical Reviews™ in Eukaryotic Gene Expression

Published 6 issues per year

ISSN Print: 1045-4403

ISSN Online: 2162-6502

The Impact Factor measures the average number of citations received in a particular year by papers published in the journal during the two preceding years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) IF: 1.6 To calculate the five year Impact Factor, citations are counted in 2017 to the previous five years and divided by the source items published in the previous five years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) 5-Year IF: 2.2 The Immediacy Index is the average number of times an article is cited in the year it is published. The journal Immediacy Index indicates how quickly articles in a journal are cited. Immediacy Index: 0.3 The Eigenfactor score, developed by Jevin West and Carl Bergstrom at the University of Washington, is a rating of the total importance of a scientific journal. Journals are rated according to the number of incoming citations, with citations from highly ranked journals weighted to make a larger contribution to the eigenfactor than those from poorly ranked journals. Eigenfactor: 0.00058 The Journal Citation Indicator (JCI) is a single measurement of the field-normalized citation impact of journals in the Web of Science Core Collection across disciplines. The key words here are that the metric is normalized and cross-disciplinary. JCI: 0.33 SJR: 0.345 SNIP: 0.46 CiteScore™:: 2.5 H-Index: 67

Indexed in

Interleukins in the Control of Osteoclast Differentiation

Volume 8, Issue 2, 1998, pp. 107-123
DOI: 10.1615/CritRevEukarGeneExpr.v8.i2.10
Get accessGet access

ABSTRACT

To maintain homeostasis of bone, the production of osteoblasts and osteoclasts is tightly regulated. At the local level, hormones and cytokines control formation of osteoclasts from hemopoietic precursors by acting upon osteoblastic-stromal cells and in some cases also upon cells of the immune system. Osteoblasts regulate osteoclast formation by providing physical support and cytokines such as M-CSF and IL-11, which promote osteoclast differentiation. Osteoblasts are also a source of IL-18, which limits osteoclast formation. The requirement of contact between osteoblasts and hemopoietic cells for successful osteoclast formation led to a concept of a membrane-anchored stromal cell molecule that programs osteoclast differentiation. This mechanism has been highlighted by the discovery of osteoprotegerin (OPG), a soluble tumor necrosis factor (TNF) family member that inhibits osteoclast formation. The ligand for OPG is a novel transmembrane TNF receptor superfamily member, the osteoclast differentiating factor (ODF). The recognition of the osteoprotegerin/osteoprotegerin-ligand axis will lead to new insights into the control of osteoclast differentiation by interleukins.

CITED BY
  1. Liu Xin‐Hua, Kirschenbaum Alexander, Yao Shen, Levine Alice C., The Role of the Interleukin‐6/gp130 Signaling Pathway in Bone Metabolism, in Interleukins, 74, 2006. Crossref

  2. Guise Theresa A., Kozlow Wende M., Heras-Herzig Ailleen, Padalecki Susan S., Yin Juan Juan, Chirgwin John M., Molecular Mechanisms of Breast Cancer Metastases to Bone, Clinical Breast Cancer, 5, 2005. Crossref

  3. Harada Suguru, Mizoguchi Toshihide, Kobayashi Yasuhiro, Nakamichi Yuko, Takeda Satoshi, Sakai Sadaoki, Takahashi Fumiaki, Saito Hitoshi, Yasuda Hisataka, Udagawa Nobuyuki, Suda Tatsuo, Takahashi Naoyuki, Daily administration of eldecalcitol (ED-71), an active vitamin D analog, increases bone mineral density by suppressing RANKL expression in mouse trabecular bone, Journal of Bone and Mineral Research, 27, 2, 2012. Crossref

  4. Mundy Gregory R., Oyajobi Babatunde, Gutierrez Gloria, Sterling Julie, Padalecki Susan, Elefteriou Florent, Zhao Ming, Cytokines and Bone Remodeling, in Fundamentals of Osteoporosis, 2010. Crossref

  5. Whitfield James F., Morley Paul, Willick Gordon E., , 65, 2002. Crossref

  6. Fleisch Herbert, Bone physiology, in Bisphosphonates in Bone Disease, 2000. Crossref

  7. Neale Susan D., Haynes David R., Howie Donald W., Murray David W., Athanasou Nicholas A., The effect of particle phagocytosis and metallic wear particles on osteoclast formation and bone resorption in vitro, The Journal of Arthroplasty, 15, 5, 2000. Crossref

  8. Holmlund Anders, Hanstrom Lennart, Lerner Ulf H., Bone resorbing activity and cytokine levels in gingival crevicular fluid before and after treatment of periodontal disease, Journal of Clinical Periodontology, 31, 6, 2004. Crossref

  9. Lundberg Pernilla, Lerner Ulf H., Expression and regulatory role of receptors for vasoactive intestinal peptide in bone cells, Microscopy Research and Technique, 58, 2, 2002. Crossref

  10. Lee Ji-Won, Mase Naomi, Yonezawa Takayuki, Seo Hwa-Jeong, Jeon Won Bae, Cha Byung Yoon, Nagai Kazuo, Woo Je-Tae, Palmatine Attenuates Osteoclast Differentiation and Function through Inhibition of Receptor Activator of Nuclear Factor-.KAPPA.B Ligand Expression in Osteoblast Cells, Biological and Pharmaceutical Bulletin, 33, 10, 2010. Crossref

  11. Kotake Shigeru, Udagawa Nobuyuki, Takahashi Naoyuki, Matsuzaki Kenichiro, Itoh Kanami, Ishiyama Shigeru, Saito Seiji, Inoue Kazuhiko, Kamatani Naoyuki, Gillespie Matthew T., Martin T. John, Suda Tatsuo, IL-17 in synovial fluids from patients with rheumatoid arthritis is a potent stimulator of osteoclastogenesis, Journal of Clinical Investigation, 103, 9, 1999. Crossref

  12. Maugeri D., Mamazza C., Giudice F. Lo, Puglisi N., Muscoso E.G., Rizzotto M., Testaì M., Bennati E., Lentini A., Panebianco P., Interleukin-18 (IL-18) and matrix metalloproteinase-9 (MMP-9) in post-menopausal osteoporosis, Archives of Gerontology and Geriatrics, 40, 3, 2005. Crossref

  13. Kallen Karl-Josef, Galle Peter Robert, Rose-John Stefan, New developments in IL-6 dependent biology and therapy: where do we stand and what are the options?, Expert Opinion on Investigational Drugs, 8, 9, 1999. Crossref

  14. Mizoguchi Toshihide, Muto Akinori, Udagawa Nobuyuki, Arai Atsushi, Yamashita Teruhito, Hosoya Akihiro, Ninomiya Tadashi, Nakamura Hiroaki, Yamamoto Yohei, Kinugawa Saya, Nakamura Midori, Nakamichi Yuko, Kobayashi Yasuhiro, Nagasawa Sakae, Oda Kimimitsu, Tanaka Hirofumi, Tagaya Mitsuo, Penninger Josef M., Ito Michio, Takahashi Naoyuki, Identification of cell cycle–arrested quiescent osteoclast precursors in vivo, Journal of Cell Biology, 184, 4, 2009. Crossref

  15. Hu Yun Shan, Zhou Hong, Myers Damian, Quinn Julian MW, Atkins Gerald J, Ly Chi, Gange Christine, Kartsogiannis Vicky, Elliott Jan, Kostakis Panagiota, Zannettino Andrew CW, Cromer Brett, Mckinstry William J, Findlay David M, Gillespie Matthew T, Ng Kong Wah, Isolation of a Human Homolog of Osteoclast Inhibitory Lectin That Inhibits the Formation and Function of Osteoclasts, Journal of Bone and Mineral Research, 19, 1, 2003. Crossref

  16. Quinn Julian M. W., Itoh Kanami, Udagawa Nobuyuki, Häusler Karl, Yasuda Hisataka, Shima Nobuyuki, Mizuno Atsuko, Higashio Kanji, Takahashi Naoyuki, Suda Tatsuo, Martin T. John, Gillespie Matthew T., Transforming Growth Factor β Affects Osteoclast Differentiation via Direct and Indirect Actions, Journal of Bone and Mineral Research, 16, 10, 2001. Crossref

  17. Whitfield James, Morley Paul, Willick Gordon, The parathyroid hormone, its fragments and analogues - potent bone-builders for treating osteoporosis, Expert Opinion on Investigational Drugs, 9, 6, 2000. Crossref

  18. Proposed Standard Nomenclature for New Tumor Necrosis Factor Family Members Involved in the Regulation of Bone Resorption, Journal of Bone and Mineral Research, 15, 12, 2000. Crossref

  19. Atkins Gerald J., Haynes David R., Graves Stephen E., Evdokiou Andreas, Hay Shelley, Bouralexis Stelios, Findlay David M., Expression of Osteoclast Differentiation Signals by Stromal Elements of Giant Cell Tumors, Journal of Bone and Mineral Research, 15, 4, 2010. Crossref

  20. Fazzalari Nicola L., Kuliwaba Julia S., Atkins Gerald J., Forwood Mark R., Findlay David M., The Ratio of Messenger RNA Levels of Receptor Activator of Nuclear Factor κB Ligand to Osteoprotegerin Correlates with Bone Remodeling Indices in Normal Human Cancellous Bone but Not in Osteoarthritis, Journal of Bone and Mineral Research, 16, 6, 2001. Crossref

  21. Zhang Dongliang, Goetz Werner, Braumann Bert, Bourauel Christoph, Jaeger Andreas, Effect of soluble receptors to interleukin-1 and tumor necrosis factor alpha on experimentally induced root resorption in rats, Journal of Periodontal Research, 38, 3, 2003. Crossref

  22. Atkins G.J, Haynes D.R, Geary S.M, Loric M, Crotti T.N, Findlay D.M, Coordinated cytokine expression by stromal and hematopoietic cells during human osteoclast formation, Bone, 26, 6, 2000. Crossref

  23. Yang Shufeng, Ding Wei, Feng Dapeng, Gong Haiyang, Zhu Dongmei, Chen Bin, Chen Jianmin, Loss of B cell regulatory function is associated with delayed healing in patients with tibia fracture, APMIS, 123, 11, 2015. Crossref

  24. MUNDY GREGORY R., OYAJOBI BABATUNDE, GUTIERREZ GLORIA, STERLING JULIE, PADALECKI SUSAN, ELEFTERIOU FLORENT, ZHAO MING, Cytokines and Bone Remodeling, in Osteoporosis, 2008. Crossref

  25. MARTIN T. JOHN, RODAN GIDEON A., Intercellular Communication during Bone Remodeling, in Osteoporosis, 2008. Crossref

  26. Dinarello Charles A., Interleukin-18, Methods, 19, 1, 1999. Crossref

  27. Proposed standard nomenclature for new tumor necrosis factor members involved in the regulation of bone resorption, Bone, 27, 6, 2000. Crossref

  28. Eskan Mehmet Akif, Greenwell Henry, Theoretical and Clinical Considerations for Autologous Blood Preparations: Platelet-Rich Plasma, Fibrin Sealants, and Plasma-Rich Growth Factors, Clinical Advances in Periodontics, 1, 2, 2011. Crossref

  29. Martin T. John, Rodan Gideon A., Intercellular Communication during Bone Remodeling, in Fundamentals of Osteoporosis, 2010. Crossref

  30. Dinarello Charles A., IL-18: A TH1 -inducing, proinflammatory cytokine and new member of the IL-1 family, Journal of Allergy and Clinical Immunology, 103, 1, 1999. Crossref

  31. Gorny Genevieve, Shaw Aubie, Oursler Merry Jo, IL-6, LIF, and TNF-α regulation of GM-CSF inhibition of osteoclastogenesis in vitro, Experimental Cell Research, 294, 1, 2004. Crossref

  32. Olsen B.R, Genetic regulation of skeletal patterning, differentiation, and growth, Bone, 25, 1, 1999. Crossref

  33. Muto Akinori, Mizoguchi Toshihide, Udagawa Nobuyuki, Ito Susumu, Kawahara Ichiro, Abiko Yoshimitsu, Arai Atsushi, Harada Suguru, Kobayashi Yasuhiro, Nakamichi Yuko, Penninger Josef M, Noguchi Toshihide, Takahashi Naoyuki, Lineage-committed osteoclast precursors circulate in blood and settle down into bone, Journal of Bone and Mineral Research, 26, 12, 2011. Crossref

  34. Romas Evan, Bone loss in inflammatory arthritis: mechanisms and therapeutic approaches with bisphosphonates, Best Practice & Research Clinical Rheumatology, 19, 6, 2005. Crossref

  35. Johnson C.S, Jerome C.P, Brommage R, Unbiased determination of cytokine localization in bone: colocalization of interleukin-6 with osteoblasts in serial sections from monkey vertebrae, Bone, 26, 5, 2000. Crossref

  36. Martin T. John, Sims Natalie A., Osteoclast-derived activity in the coupling of bone formation to resorption, Trends in Molecular Medicine, 11, 2, 2005. Crossref

  37. Atkins G.J, Bouralexis S, Haynes D.R, Graves S.E, Geary S.M, Evdokiou A, Zannettino A.C.W, Hay S, Findlay D.M, Osteoprotegerin inhibits osteoclast formation and bone resorbing activity in giant cell tumors of bone, Bone, 28, 4, 2001. Crossref

  38. Richards Carl D, Langdon Carrie, Deschamps Paula, Pennica Diane, Shaughnessy Stephen G, STIMULATION OF OSTEOCLAST DIFFERENTIATION IN VITRO BY MOUSE ONCOSTATIN M, LEUKAEMIA INHIBITORY FACTOR, CARDIOTROPHIN-1 AND INTERLEUKIN 6: SYNERGY WITH DEXAMETHASONE, Cytokine, 12, 6, 2000. Crossref

  39. Sakai Akihiko, Ohshima Mitsuhiro, Sugano Naoyuki, Otsuka Kichibee, Ito Koichi, Profiling the Cytokines in Gingival Crevicular Fluid Using a Cytokine Antibody Array, Journal of Periodontology, 77, 5, 2006. Crossref

  40. Choi Bong-Kyu, Ohk Seung-Ho, Lee Hyun Jung, Kang Jung Hwa, Jeong Gook Jin, Yoo Yun-Jung, Effects of Whole Cell Sonicates ofTreponema lecithinolyticumon Osteoclast Differentiation, Journal of Periodontology, 72, 9, 2001. Crossref

  41. Najar Mehdi, Fayyad-Kazan Hussein, Faour Wissam H., Badran Bassam, Journe Fabrice, Lagneaux Laurence, Breast cancer cells and bone marrow mesenchymal stromal cells: a regulated modulation of the breast tumor in the context of immune response, Inflammation Research, 66, 2, 2017. Crossref

  42. Tintut Yin, Parhami Farhad, Tsingotjidou Anastasia, Tetradis Sotirios, Territo Mary, Demer Linda L., 8-Isoprostaglandin E2 Enhances Receptor-activated NFκB Ligand (RANKL)-dependent Osteoclastic Potential of Marrow Hematopoietic Precursors via the cAMP Pathway, Journal of Biological Chemistry, 277, 16, 2002. Crossref

  43. Martin T John, Reflecting on Some Discoveries of 40 Years and Their Outcomes, Journal of Bone and Mineral Research, 32, 10, 2017. Crossref

  44. Liu Y., Wang L., Liu S., Liu D., Chen C., Xu X., Chen X., Shi S., Transplantation of SHED Prevents Bone Loss in the Early Phase of Ovariectomy-induced Osteoporosis, Journal of Dental Research, 93, 11, 2014. Crossref

  45. Chaiya Inthira, Rattanakul Chontita, An impulsive mathematical model of bone formation and resorption: effects of parathyroid hormone, calcitonin and impulsive estrogen supplement, Advances in Difference Equations, 2017, 1, 2017. Crossref

  46. Palmqvist P., Lundberg P., Lundgren I., Hänström L., Lerner U.H., IL-1β and TNF-α Regulate IL-6-type Cytokines in Gingival Fibroblasts, Journal of Dental Research, 87, 6, 2008. Crossref

  47. Lerner U.H., Inflammation-induced Bone Remodeling in Periodontal Disease and the Influence of Post-menopausal Osteoporosis, Journal of Dental Research, 85, 7, 2006. Crossref

  48. HSU YU-CHIEH, CHENG CHIA-PI, CHANG DEH-MING, Plectranthus amboinicus Attenuates Inflammatory Bone Erosion in Mice with Collagen-induced Arthritis by Downregulation of RANKL-induced NFATc1 Expression, The Journal of Rheumatology, 38, 9, 2011. Crossref

  49. Gomes Brenda Paula Figueiredo de Almeida, Herrera Daniel Rodrigo, Etiologic role of root canal infection in apical periodontitis and its relationship with clinical symptomatology, Brazilian Oral Research, 32, suppl 1, 2018. Crossref

  50. Lerner Ulf H., Lundberg Pernilla, Kinins and Neuro-osteogenic Factors, in Principles of Bone Biology, 2002. Crossref

  51. Lee Cassandra A., Einhorn Thomas A., The Bone Organ System, in Osteoporosis, 2001. Crossref

  52. Martin Thomas J., Rodan Gideon A., Coupling of Bone Resorption and Formation during Bone Remodeling, in Osteoporosis, 2001. Crossref

  53. Mundy Gregory R., Oyajobi Babatunde, Traianedes Kathy, Dallas Sarah, Chen Di, Cytokines and Bone Remodeling, in Osteoporosis, 2001. Crossref

  54. Li Xiaotong, Udagawa Nobuyuki, Itoh Kanami, Suda Koji, Murase Yoshiyuki, Nishihara Tatsuji, Suda Tatsuo, Takahashi Naoyuki, p38 MAPK-Mediated Signals Are Required for Inducing Osteoclast Differentiation But Not for Osteoclast Function, Endocrinology, 143, 8, 2002. Crossref

  55. Wang Meijing, Markel Troy A., Meldrum Daniel R., INTERLEUKIN 18 IN THE HEART, Shock, 30, 1, 2008. Crossref

  56. Suda Tatsuo, Takahashi Naoyuki, Udagawa Nobuyuki, Jimi Eijiro, Gillespie Matthew T., Martin T. John, Modulation of Osteoclast Differentiation and Function by the New Members of the Tumor Necrosis Factor Receptor and Ligand Families, Endocrine Reviews, 20, 3, 1999. Crossref

  57. Alippe Yael, Mbalaviele Gabriel, Omnipresence of inflammasome activities in inflammatory bone diseases, Seminars in Immunopathology, 41, 5, 2019. Crossref

  58. Vanderschueren D., Vandenput L., Verstuyf A., Swinnen JV., Bouillon R., Boonen S., Androgens, Skeletal Homeostasis, and Osteoporosis, in Androgens and Androgen Receptor, 2002. Crossref

  59. Lubberts Erik, van den Berg Wim B., Cytokine regulation of bone destruction, in Cytokines and Joint Injury, 2004. Crossref

  60. Palmqvist Py, Persson Emma, Conaway H. Herschel, Lerner Ulf H., IL-6, Leukemia Inhibitory Factor, and Oncostatin M Stimulate Bone Resorption and Regulate the Expression of Receptor Activator of NF-κB Ligand, Osteoprotegerin, and Receptor Activator of NF-κB in Mouse Calvariae, The Journal of Immunology, 169, 6, 2002. Crossref

  61. Khapli Shruti M., Mangashetti Latha S., Yogesha S. D., Wani Mohan R., IL-3 Acts Directly on Osteoclast Precursors and Irreversibly Inhibits Receptor Activator of NF-κB Ligand-Induced Osteoclast Differentiation by Diverting the Cells to Macrophage Lineage, The Journal of Immunology, 171, 1, 2003. Crossref

  62. Berger Steph M., Griffin Jacob S., Dent Sophia C., Phenotypes and pathways: Working toward an integrated skeletal biology in biological anthropology, American Journal of Human Biology, 33, 2, 2021. Crossref

  63. Spelsberg Thomas C., Subramaniam M., Riggs B. Lawrence, Khosla Sundeep, The Actions and Interactions of Sex Steroids and Growth Factors/Cytokines on the Skeleton, Molecular Endocrinology, 13, 6, 1999. Crossref

  64. Lorenzo Joseph, Horowitz Mark, Choi Yongwon, Osteoimmunology: Interactions of the Bone and Immune System, Endocrine Reviews, 29, 4, 2008. Crossref

  65. Thomas Rachel J., Guise Theresa A., Yin Juan Juan, Elliott Jan, Horwood Nicole J., Martin T. John, Gillespie Matthew T., Breast Cancer Cells Interact with Osteoblasts to Support Osteoclast Formation1, Endocrinology, 140, 10, 1999. Crossref

  66. Auernhammer C. J., Melmed S., Leukemia-Inhibitory Factor—Neuroimmune Modulator of Endocrine Function*, Endocrine Reviews, 21, 3, 2000. Crossref

  67. Arai Atsushi, Mizoguchi Toshihide, Harada Suguru, Kobayashi Yasuhiro, Nakamichi Yuko, Yasuda Hisataka, Penninger Josef M., Yamada Kazuhiro, Udagawa Nobuyuki, Takahashi Naoyuki, c-Fos plays an essential role in the up-regulation of RANK expression in osteoclast precursors within the bone microenvironment, Journal of Cell Science, 2012. Crossref

  68. Nishida Daisuke, Arai Atsushi, Zhao Lijuan, Yang Mengyu, Nakamichi Yuko, Horibe Kanji, Hosoya Akihiro, Kobayashi Yasuhiro, Udagawa Nobuyuki, Mizoguchi Toshihide, RANKL/OPG ratio regulates odontoclastogenesis in damaged dental pulp, Scientific Reports, 11, 1, 2021. Crossref

  69. Walsh Matthew C., Kim Nacksung, Kadono Yuho, Rho Jaerang, Lee Soo Young, Lorenzo Joseph, Choi Yongwon, OSTEOIMMUNOLOGY: Interplay Between the Immune System and Bone Metabolism, Annual Review of Immunology, 24, 1, 2006. Crossref

  70. Nakanishi Kenji, Yoshimoto Tomohiro, Tsutsui Hiroko, Okamura Haruki, Interleukin-18 Regulates Both Th1 and Th2 Responses, Annual Review of Immunology, 19, 1, 2001. Crossref

  71. Balkwill Frances R, Cytokines, in eLS, 2001. Crossref

  72. Takuma Atsushi, Kaneda Toshio, Sato Takuya, Ninomiya Setsuo, Kumegawa Masayoshi, Hakeda Yoshiyuki, Dexamethasone Enhances Osteoclast Formation Synergistically with Transforming Growth Factor-β by Stimulating the Priming of Osteoclast Progenitors for Differentiation into Osteoclasts, Journal of Biological Chemistry, 278, 45, 2003. Crossref

  73. Palmqvist Py, Lundberg Pernilla, Persson Emma, Johansson Anders, Lundgren Inger, Lie Anita, Conaway H. Herschel, Lerner Ulf H., Inhibition of Hormone and Cytokine-stimulated Osteoclastogenesis and Bone Resorption by Interleukin-4 and Interleukin-13 Is Associated with Increased Osteoprotegerin and Decreased RANKL and RANK in a STAT6-dependent Pathway, Journal of Biological Chemistry, 281, 5, 2006. Crossref

  74. Zhou Hong, Kartsogiannis Vicky, Hu Yun Shan, Elliott Jan, Quinn Julian M.W., McKinstry William J., Gillespie Matthew T., Ng Kong Wah, A Novel Osteoblast-derived C-type Lectin That Inhibits Osteoclast Formation, Journal of Biological Chemistry, 276, 18, 2001. Crossref

  75. Moore R. N., Bost Kenneth L., Bento Jennifer L., Ellington John K., Marriott Ian, Hudson Michael C., Induction of Colony-Stimulating Factor Expression following Staphylococcus or Salmonella Interaction with Mouse or Human Osteoblasts , Infection and Immunity, 68, 9, 2000. Crossref

  76. Lee Ji-Won, Kobayashi Yasuhiro, Nakamichi Yuko, Udagawa Nobuyuki, Takahashi Naoyuki, Im Nam-Kyung, Seo Hwa-Jeong, Jeon Won Bae, Yonezawa Takayuki, Cha Byung-Yoon, Woo Je-Tae, Alisol-B, a novel phyto-steroid, suppresses the RANKL-induced osteoclast formation and prevents bone loss in mice, Biochemical Pharmacology, 80, 3, 2010. Crossref

  77. Zhu Hao, Haugen Håvard Jostein, Perale Giuseppe, Elin Reseland Janne, Parreiras Nogueira Liebert, Gonzalez Cantalapiedra Antonio, Maria Guzon Muñoz Fernando, Permuy Mendaña Maria, Betge Felice, Petter Lyngstadaas Ståle, Xiao Jun, Tailoring Resorption Rates and Osteogenic Response in Xeno-Hybrid Bone Grafts: The Effect of Added Gelatins, Engineering, 13, 2022. Crossref

  78. Dinarello C A, Novel targets for interleukin 18 binding protein, Annals of the Rheumatic Diseases, 60, suppl 3, 2001. Crossref

  79. Kalkar Prajakta, Cohen Gal, Tamari Tal, Schif-Zuck Sagie, Zigdon-Giladi Hadar, Ariel Amiram, IFN-β mediates the anti-osteoclastic effect of bisphosphonates and dexamethasone, Frontiers in Pharmacology, 13, 2022. Crossref

Forthcoming Articles

PRMT6 promotes the immune evasion of gastric cancer via upregulating ANXA1 Liang Xu, Fenger Zhang, Binqi Yu, Shengnan Jia, Sunfu Fan PURPL promotes M2 macrophage polarization in lung cancer via regulating RBM4/xCT signaling Jipeng Guo, Chongwen Gong, Hao Wang SIAH1 promotes the pyroptosis of cardiomyocytes in diabetic cardiomyopathy via regulating IκB-α/NF-κB signaling Jinbin Wu, Yaoming Yan SLC7A2-mediated lysine catabolism inhibits immunosuppression in triple negative breast cancer Yuanyuan Sun, Yaqing Li, Chengying Jiang, Chenying Liu, Yuanming Song SIAH2-mediated degradation of ACSL4 inhibits the anti-tumor activity of CD8+ T cells in hepatocellular carcinoma Fangzheng Shu, Yuhua Shi, Xiangxiang Shan, Wenzhang Zha, Rengen Fan, Wanjiang Xue RBM15-mediated N6-methyl adenosine (m6A) modification of EZH2 drives the epithelial-mesenchymal transition of cervical cancer Ruixue Wang, Wenhua Tan Evidence-Based Storytelling and A Strategic Roadmap to Promote Cancer Prevention Via Adolescent HPV Vaccination in Northern New England Matthew Dugan, Gary Stein, Jan Carney, Sheila Clifford-Bova KDM4A-AS1 promotes cell proliferation, migration and invasion via the miR-4306/STX6 axis in hepatocellular carcinoma Wei Cao, Yuhan Ren, Ying Liu, Guoshu Cao, Zhen Chen, Fan Wang HDAC1-mediated downregulation of NEU1 exacerbates the aggressiveness of cervical cancer Nanzi Xie, Sisi Mei, Changlan Dai, Wei Chen Effect of miR-26b-5p on progression of acute myeloid leukemia by regulating USP48-mediated Wnt/β-catenin pathway Yu Xie, Lin Tan, Kun Wu, Deyun Li, Chengping Li
Begell Digital Portal Begell Digital Library eBooks Journals References & Proceedings Research Collections Prices and Subscription Policies Begell House Contact Us Language English 中文 Русский Português German French Spain