Published 8 issues per year
ISSN Print: 1045-4403
ISSN Online: 2162-6502
Indexed in
Sirtuins in Brain Aging and Neurological Disorders
ABSTRACT
The many ways of aging have been and continue to be investigated. For this reason, over many years, several studies have resolved some of the genetic details underlying aging processes. It resulted in the identification of a yeast gene known as Sir2, which is a longevity modulator. Sir2 and SIRT1 are the mammalian homologs of yeast genes. Sirtuins (including SIRT1) play an important role in aging of the brain and the metabolic regulation pathway in mammals. Aging in the brain is caused by the loss of neurophysiologic functions due to neurodegeneration. The sirtuin family plays a central role in the beneficial effects of calorie restriction (CR). CR is linked with an increase in life span and decrease in the risk of diseases related to the brain. Sirtuins may be helpful for us in studying the process of aging and treatment of diseases related with aging.
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Ma Yongmei , Fei Xiaoqiang , SIRT5 regulates pancreatic β‑cell proliferation and insulin secretion in type 2 diabetes, Experimental and Therapeutic Medicine, 2018. Crossref
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Yu Mengdi, Zhang Hongxia, Wang Brian, Zhang Yinuo, Zheng Xiaoying, Shao Bei, Zhuge Qichuan, Jin Kunlin, Key Signaling Pathways in Aging and Potential Interventions for Healthy Aging, Cells, 10, 3, 2021. Crossref
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Deng Hong‐Ji, Zhou Chen‐Hui, Huang Li‐Tian, Wen Liang‐Bao, Zhou Meng‐Liang, Wang Chun‐Xi, Activation of silent information regulator 1 exerts a neuroprotective effect after intracerebral hemorrhage by deacetylating NF‐κB/p65, Journal of Neurochemistry, 157, 3, 2021. Crossref
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Islam Fahadul, Nafady Mohamed H., Islam Md. Rezaul, Saha Susmita, Rashid Salma, Akter Aklima, Or-Rashid Md. Harun-, Akhtar Muhammad Furqan, Perveen Asma, Md. Ashraf Ghulam, Rahman Md. Habibur, Hussein Sweilam Sherouk, Resveratrol and neuroprotection: an insight into prospective therapeutic approaches against Alzheimer’s disease from bench to bedside, Molecular Neurobiology, 59, 7, 2022. Crossref
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Kumar Vishal, Kundu Satyabrata, Singh Arti, Singh Shamsher, Understanding the Role of Histone Deacetylase and their Inhibitors in Neurodegenerative Disorders: Current Targets and Future Perspective, Current Neuropharmacology, 20, 1, 2022. Crossref
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Fang Chaoyou, Xu Houshi, Yuan Ling, Zhu Zhengyang, Wang Xiaoyu, Liu Yibo, Zhang Anke, Shao Anwen, Lou Meiqing, Zhang Xiangsheng, Natural Compounds for SIRT1-Mediated Oxidative Stress and Neuroinflammation in Stroke: A Potential Therapeutic Target in the Future, Oxidative Medicine and Cellular Longevity, 2022, 2022. Crossref