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Critical Reviews™ in Eukaryotic Gene Expression

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Hedgehog Signaling in Hematopoiesis

Volume 20, Issue 2, 2010, pp. 129-139
DOI: 10.1615/CritRevEukarGeneExpr.v20.i2.30
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Yiting Lim
The Sidney Kimmel Comprehensive Cancer Center and Department of Oncology, Johns Hopkins University School of Medicine, Baltimore, Maryland
William Matsui
The University of Texas at Austin, Dell Medical School

ABSTRACT

The Hedgehog signaling pathway is highly conserved and plays an essential role in the embryonic development of a wide variety of organs. In adult tissues, such as the central nervous system, it may also be required for homeostasis and repair following injury. The role of Hedgehog signaling in regulating hematopoiesis is not entirely clear. Evidence has shown that Hedgehog signaling is required for both primitive hematopoiesis in the developing embryo, as well as for definitive hematopoiesis in the adult. However, several studies also suggest that Hedgehog pathway activity is completely dispensable in postnatal hematopoiesis. In this review, we discuss the current understanding of Hedgehog signaling in vertebrate hematopoiesis, as well as the contradictory findings that have been reported.

KEY WORDS: Hedgehog signaling, hematopoiesis, hematopoietic stem cells
CITED BY

  1. Gruber Tanja A., Larson Gedman Amanda, Zhang Jinghui, Koss Cary S., Marada Suresh, Ta Huy Q., Chen Shann-Ching, Su Xiaoping, Ogden Stacey K., Dang Jinjun, Wu Gang, Gupta Vedant, Andersson Anna K., Pounds Stanley, Shi Lei, Easton John, Barbato Michael I., Mulder Heather L., Manne Jayanthi, Wang Jianmin, Rusch Michael, Ranade Swati, Ganti Ramapriya, Parker Matthew, Ma Jing, Radtke Ina, Ding Li, Cazzaniga Giovanni, Biondi Andrea, Kornblau Steven M., Ravandi Farhad, Kantarjian Hagop, Nimer Stephen D., Döhner Konstanze, Döhner Hartmut, Ley Timothy J., Ballerini Paola, Shurtleff Sheila, Tomizawa Daisuke, Adachi Souichi, Hayashi Yasuhide, Tawa Akio, Shih Lee-Yung, Liang Der-Cherng, Rubnitz Jeffrey E., Pui Ching-Hon, Mardis Elaine R., Wilson Richard K., Downing James R., An Inv(16)(p13.3q24.3)-Encoded CBFA2T3-GLIS2 Fusion Protein Defines an Aggressive Subtype of Pediatric Acute Megakaryoblastic Leukemia, Cancer Cell, 22, 5, 2012. Crossref

  2. Fossett Nancy, Signal transduction pathways, intrinsic regulators, and the control of cell fate choice, Biochimica et Biophysica Acta (BBA) - General Subjects, 1830, 2, 2013. Crossref

  3. Pamies David, Vilanova Eugenio, Sogorb Miguel A., Functional pathways altered after silencing Pnpla6 (the codifying gene of neuropathy target esterase) in mouse embryonic stem cells under differentiation, In Vitro Cellular & Developmental Biology - Animal, 50, 3, 2014. Crossref

  4. Khan Alesia A., Harrison Claire N., McLornan Donal P., Targeting of the Hedgehog pathway in myeloid malignancies: still a worthy chase?, British Journal of Haematology, 170, 3, 2015. Crossref

  5. Crisan Mihaela, Solaimani Kartalaei Parham, Neagu Alex, Karkanpouna Sofia, Yamada-Inagawa Tomoko, Purini Caterina, Vink Chris S., van der Linden Reinier, van Ijcken Wilfred, Chuva de Sousa Lopes Susana M., Monteiro Rui, Mummery Christine, Dzierzak Elaine, BMP and Hedgehog Regulate Distinct AGM Hematopoietic Stem Cells Ex Vivo, Stem Cell Reports, 6, 3, 2016. Crossref

  6. Baldeosingh Rajkumar, Gao Hongjuan, Wu Xiaorong, Fossett Nancy, Hedgehog signaling from the Posterior Signaling Center maintains U-shaped expression and a prohemocyte population in Drosophila, Developmental Biology, 441, 1, 2018. Crossref

  7. Pession Andrea, Lonetti Annalisa, Bertuccio Salvatore, Locatelli Franco, Masetti Riccardo, Targeting Hedgehog pathway in pediatric acute myeloid leukemia: challenges and opportunities, Expert Opinion on Therapeutic Targets, 23, 2, 2019. Crossref

  8. Lonetti Annalisa, Pession Andrea, Masetti Riccardo, Targeted Therapies for Pediatric AML: Gaps and Perspective, Frontiers in Pediatrics, 7, 2019. Crossref

  9. Peer Elisabeth, Tesanovic Suzana, Aberger Fritz, Next-Generation Hedgehog/GLI Pathway Inhibitors for Cancer Therapy, Cancers, 11, 4, 2019. Crossref

  10. Clara Joseph A., Monge Cecilia, Yang Yingzi, Takebe Naoko, Targeting signalling pathways and the immune microenvironment of cancer stem cells — a clinical update, Nature Reviews Clinical Oncology, 17, 4, 2020. Crossref

  11. Singh Sakshi, Singh Vinay K., Rai Geeta, Identification of Differentially Expressed Hematopoiesis-associated Genes in Term Low Birth Weight Newborns by Systems Genomics Approach, Current Genomics, 20, 7, 2020. Crossref

  12. Gurnari Carmelo, Voso Maria Teresa, Maciejewski Jaroslaw P., Visconte Valeria, From Bench to Bedside and Beyond: Therapeutic Scenario in Acute Myeloid Leukemia, Cancers, 12, 2, 2020. Crossref

  13. Sands William A, Copland Mhairi, Wheadon Helen, Targeting self-renewal pathways in myeloid malignancies, Cell Communication and Signaling, 11, 1, 2013. Crossref

  14. Wolska-Washer Anna, Robak Tadeusz, Glasdegib in the treatment of acute myeloid leukemia, Future Oncology, 15, 28, 2019. Crossref

  15. Bruveris Freya F., Ng Elizabeth S., Stanley Edouard G., Elefanty Andrew G., VEGF, FGF2, and BMP4 regulate transitions of mesoderm to endothelium and blood cells in a human model of yolk sac hematopoiesis, Experimental Hematology, 103, 2021. Crossref

  16. Abraham Ajay, Matsui William, Hedgehog Signaling in Myeloid Malignancies, Cancers, 13, 19, 2021. Crossref

  17. Wang Jinheng, Tu Chenggong, Zhang Hui, Huo Yongliang, Menu Eline, Liu Jinbao, Single-cell analysis at the protein level delineates intracellular signaling dynamic during hematopoiesis, BMC Biology, 19, 1, 2021. Crossref

  18. Petrova Ralitsa, Joyner Alexandra L., Roles for Hedgehog signaling in adult organ homeostasis and repair, Development, 141, 18, 2014. Crossref

  19. Serowoky Maxwell A., Kuwahara Stephanie T., Liu Shuwan, Vakhshori Venus, Lieberman Jay R., Mariani Francesca V., A murine model of large-scale bone regeneration reveals a selective requirement for Sonic Hedgehog, npj Regenerative Medicine, 7, 1, 2022. Crossref

  20. Chugh Rishi Man, Bhanja Payel, Olea Ximena Diaz, Tao Fang, Schroeder Kealan, Zitter Ryan, Arora Tanu, Pathak Harsh, Kimler Bruce F., Godwin Andrew K., Perry John M., Saha Subhrajit, Human Peripheral Blood Mononucleocyte Derived Myeloid Committed Progenitor Cells Mitigate H-ARS by Exosomal Paracrine Signal, International Journal of Molecular Sciences, 23, 10, 2022. Crossref

  21. Mar B G, Amakye D, Aifantis I, Buonamici S, The controversial role of the Hedgehog pathway in normal and malignant hematopoiesis, Leukemia, 25, 11, 2011. Crossref

  22. Sharma Shiv Kumar, Ghosh Saikat, Geetha Aarathy RavisundarJose, Mandal Sudip, Mandal Lolitika, Cell Adhesion-Mediated Actomyosin Assembly Regulates the Activity of Cubitus Interruptus for Hematopoietic Progenitor Maintenance in Drosophila , Genetics, 212, 4, 2019. Crossref

  23. Tesanovic Suzana, Krenn Peter W., Aberger Fritz, Hedgehog/GLI signaling in hematopoietic development and acute myeloid leukemia—From bench to bedside, Frontiers in Cell and Developmental Biology, 10, 2022. Crossref

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