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Critical Reviews™ in Eukaryotic Gene Expression
IF: 1.734 5-Year IF: 1.848 SJR: 0.627 SNIP: 0.516 CiteScore™: 1.96

ISSN Print: 1045-4403
ISSN Online: 2162-6502

Critical Reviews™ in Eukaryotic Gene Expression

DOI: 10.1615/CritRevEukaryotGeneExpr.2015012469
pages 47-57

The Role Of Semaphorin 3A In The Skeletal System

Peifu Tang
Department of Orthopaedics, Chinese PLA General Hospital, Beijing China
Pengbin Yin
Department of Orthopaedics, Chinese PLA General Hospital, Beijing China
Houchen Lv
Department of Orthopaedics, Chinese PLA General Hospital, Beijing China
Licheng Zhang
Department of Orthopaedics, Chinese PLA General Hospital, Beijing China
Lihai Zhang
Department of Orthopaedics, Chinese PLA General Hospital, Beijing China

ABSTRACT

Semaphorin 3A (Sema3A), characterized by a conserved N-terminal "Sema" domain, was originally described as an axon guidance molecule. Recent research indicates that it performs a critical function in the skeletal system. This review highlights recent advances in understanding of the role of Sema3A in the skeletal system as a regulator of bone metabolism and as a potential drug target for bone disease therapy. We summarize Sema3A functions in osteoblastogenesis and osteoclastogenesis, as well as in innervation, and we discuss its multifunctional role in various bone diseases such as osteoporosis and low back pain. Despite limited research in this field, our aim is to promote further understanding of the function of Sema3A in the skeletal system.