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Critical Reviews™ in Eukaryotic Gene Expression

Published 6 issues per year

ISSN Print: 1045-4403

ISSN Online: 2162-6502

The Impact Factor measures the average number of citations received in a particular year by papers published in the journal during the two preceding years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) IF: 1.6 To calculate the five year Impact Factor, citations are counted in 2017 to the previous five years and divided by the source items published in the previous five years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) 5-Year IF: 2.2 The Immediacy Index is the average number of times an article is cited in the year it is published. The journal Immediacy Index indicates how quickly articles in a journal are cited. Immediacy Index: 0.3 The Eigenfactor score, developed by Jevin West and Carl Bergstrom at the University of Washington, is a rating of the total importance of a scientific journal. Journals are rated according to the number of incoming citations, with citations from highly ranked journals weighted to make a larger contribution to the eigenfactor than those from poorly ranked journals. Eigenfactor: 0.00058 The Journal Citation Indicator (JCI) is a single measurement of the field-normalized citation impact of journals in the Web of Science Core Collection across disciplines. The key words here are that the metric is normalized and cross-disciplinary. JCI: 0.33 SJR: 0.345 SNIP: 0.46 CiteScore™:: 2.5 H-Index: 67

Indexed in

Calcium Signaling in Ocular Arterioles

Volume 17, Issue 1, 2007, pp. 1-12
DOI: 10.1615/CritRevEukarGeneExpr.v17.i1.10
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ABSTRACT

Local control of blood flow to the photoreceptors and associated neurons in the retina is largely achieved through changes in tone within the choroidal and retinal arterioles. This is primarily achieved through changes in [Ca2+] within the smooth muscle of these vessels, which regulates cell contraction and vascular constriction. Here we review some aspects of the cell physiology involved in these Ca2+-signaling processes, with particular emphasis on the molecular mechanisms involved. Ca2+-influx across the plasma membrane can occur via a variety of Ca2+-channels, including voltage-operated, store-operated, and receptor-operated channels. Ca2+ may also be released from intracellular stores via RyR-, or IP3R-gated channels in the SR membrane. Using high-speed confocal Ca2+-imaging, we have also demonstrated that the resulting signals are far from homogeneous, with spontaneous activity in retinal arterioles being characterized by both localized Ca2+-sparks and more global Ca2+-waves and oscillations. These signals may be specifically and differentially targeted, for example, to Ca2+-sensitive ion channels (stimulus-excitation coupling), or pathways regulating contraction (stimulus-contraction coupling). Exploring the role of changes in such targeting in disease states will provide exciting opportunities for future research.

CITED BY
  1. MCGAHON MARY K., MCKEE JONATHAN, DASH DURGA P., BROWN EOIN, SIMPSON DAVID A., CURTIS TIMOTHY M., McGEOWN JAMES G., SCHOLFIELD CHARLES N., Pharmacological Profiling of Store-Operated Ca2+Entry in Retinal Arteriolar Smooth Muscle, Microcirculation, 19, 7, 2012. Crossref

  2. Zhou Rong, Ding Xiao-li, Liu Liang-ming, Ryanodine receptor 2 contributes to hemorrhagic shock-induced bi-phasic vascular reactivity in rats, Acta Pharmacologica Sinica, 35, 11, 2014. Crossref

  3. McGeown J. Graham, Seeing is believing! Imaging Ca2+-signalling events in living cells, Experimental Physiology, 95, 11, 2010. Crossref

  4. Zhou Rong, Chen Feng, Li Qiang, Hu De-yao, Liu Liang-ming, Stimulation of the adenosine A3 receptor reverses vascular hyporeactivity after hemorrhagic shock in rats, Acta Pharmacologica Sinica, 31, 4, 2010. Crossref

  5. Misfeldt Mikkel Wölck, Aalkjaer Christian, Simonsen Ulf, Bek Toke, Voltage-gated calcium channels are involved in the regulation of calcium oscillations in vascular smooth muscle cells from isolated porcine retinal arterioles, Experimental Eye Research, 91, 1, 2010. Crossref

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