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Critical Reviews™ in Eukaryotic Gene Expression
IF: 1.841 5-Year IF: 1.927 SJR: 0.649 SNIP: 0.516 CiteScore™: 1.96

ISSN Print: 1045-4403
ISSN Online: 2162-6502

Critical Reviews™ in Eukaryotic Gene Expression

DOI: 10.1615/CritRevEukarGeneExpr.2013006033
pages 27-35

Role of Cancer-Related Inflammation in Esophageal Cancer

Mingxin Zhang
Department of Gastroenterology, Tangdu Hospital, Fourth Military Medical University, Xi'an,Shaanxi, China
Suna Zhou
Department of Radiotherapy, Tangdu Hospital, Fourth Military Medical University, Xi'an, Shaanxi, China; Department of Thoracic Oncology, First Affiliated Hospital of Medical School, Xi'an Jiaotong University
Lingmin Zhang
Department of Anesthesiology, First Affiliated Hospital, Medical School, Xi'an Jiaotong University, Xi'an 710061, Shaanxi Province, China
Wenguang Ye
Department of Gastroenterology, Tangdu Hospital, Fourth Military Medical University, Xi'an,Shaanxi, China
Qinsheng Wen
Department of Gastroenterology, Tangdu Hospital, Fourth Military Medical University, Xi'an 710038, Shaanxi Province, China
Mingxin Zhang
Department of Gastroenterology, First Affiliated Hospital of Xi'an Medical University, Shaanxi, China

ABSTRACT

Esophageal cancer (EC) is the ninth most common malignancy with a poor prognosis. It is clear that improvements need to be made to reveal the exact molecular mechanisms of EC. Cancer-related inflammation (CRI) recently has been proposed as a major physiological hallmark of malignancy and has important value in diagnosis, treatment, and prognosis. But the role of CRI in EC has remained unclear. In this review, we focus primarily on the function of key mediators of CRI in EC, including transcription factors, chemokines, cytokines, reactive oxygen species, COX-2, and specific microRNAs. Through a comprehensive analysis, we try to reveal the interaction between CRI and EC, providing novel preventive, diagnostic, and therapeutic strategies to reduce the health burden of EC.