Library Subscription: Guest
Home Begell Digital Library eBooks Journals References & Proceedings Research Collections
Critical Reviews™ in Eukaryotic Gene Expression

Impact factor: 2.385

ISSN Print: 1045-4403
ISSN Online: 2162-6502

Critical Reviews™ in Eukaryotic Gene Expression

DOI: 10.1615/CritRevEukaryotGeneExpr.v12.i1.30
12 pages

The Nuclear Receptor PXR: A Master Regulator of “Homeland” Defense

Isabelle Dussault
Division of Molecular Medicine The Beckman Research Institute, City of Hope National Medical Center, Duarte, CA 91010
Barry Marc Forman
Division of Molecular Medicine, The Gonda Diabetes and Genetic Research Center, The Beckman Research Institute, City of Hope National Medical Center, Duarte, CA 91010

ABSTRACT

Human beings are constantly exposed to toxic chemicals present in food and the environment. We are also challenged by toxic byproducts of chemical reactions within our own bodies. These toxins need to be inactivated or excreted to maintain homeostasis. Pregnane X receptor (PXR) is a promiscuous nuclear receptor that is activated by a diverse array of endogenous and exogenous toxins. On activation, PXR regulates a number of target genes involved in drug metabolism and efflux in two key target tissues: the liver and intestine. In this article, we review the data accumulated in the last few years identifying PXR as a central player in the integration of these pathways.