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Critical Reviews™ in Eukaryotic Gene Expression

Impact factor: 1.660

ISSN Print: 1045-4403
ISSN Online: 2162-6502

Critical Reviews™ in Eukaryotic Gene Expression

DOI: 10.1615/CritRevEukarGeneExpr.v15.i3.60
pages 243-254

Role of Runx Proteins in Chondrogenesis

Carolina A. Yoshida
Div.of Oral Cytology/Cell Biology,Dept.of Developmental/Reconstructive Medicine,Nagasaki University Graduate School of Biomedical Sciences,Nagasaki;and Dept.of Orthodontics/Dentofacial Orthopedics,Osaka University Graduate School of Dentistry,Osaka,Japan
Toshihisa Komori
Division of Oral Cytology and Cell Biology, Department of Developmental and Reconstructive Medicine, Nagasaki University Graduate School of Biomedical Sciences, 1 -7-1 Sakamoto, Nagasaki, Nagasaki 852-8588, Japan


The mammalian RUNX protein family comprises three transcription factors—RUNX1, RUNX2, and RUNX3. RUNX1 is involved in hematopoiesis, RUNX2 has multiple roles in osteogenesis and RUNX3 is associated with neural and gut development. In addition, all RUNX proteins are expressed during chondrogenesis, the process by which cartilage is formed. This review describes the involvement of Runx proteins in chondrogenesis, delineating their expression pattern and emphasizing their active roles in mesenchymal condensation, chondrocyte proliferation, and chondrocyte maturation. It also highlights how Runx proteins regulate transcription of target genes and how Runx proteins are regulated in the cartilaginous skeleton.