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Critical Reviews™ in Eukaryotic Gene Expression

Published 6 issues per year

ISSN Print: 1045-4403

ISSN Online: 2162-6502

The Impact Factor measures the average number of citations received in a particular year by papers published in the journal during the two preceding years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) IF: 1.6 To calculate the five year Impact Factor, citations are counted in 2017 to the previous five years and divided by the source items published in the previous five years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) 5-Year IF: 2.2 The Immediacy Index is the average number of times an article is cited in the year it is published. The journal Immediacy Index indicates how quickly articles in a journal are cited. Immediacy Index: 0.3 The Eigenfactor score, developed by Jevin West and Carl Bergstrom at the University of Washington, is a rating of the total importance of a scientific journal. Journals are rated according to the number of incoming citations, with citations from highly ranked journals weighted to make a larger contribution to the eigenfactor than those from poorly ranked journals. Eigenfactor: 0.00058 The Journal Citation Indicator (JCI) is a single measurement of the field-normalized citation impact of journals in the Web of Science Core Collection across disciplines. The key words here are that the metric is normalized and cross-disciplinary. JCI: 0.33 SJR: 0.345 SNIP: 0.46 CiteScore™:: 2.5 H-Index: 67

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The Aryl Hydrocarbon Receptor Complex and the Control of Gene Expression

Volume 18, Issue 3, 2008, pp. 207-250
DOI: 10.1615/CritRevEukarGeneExpr.v18.i3.20
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ABSTRACT

The aryl hydrocarbon receptor (AhR) is a ligand-activated transcription factor that controls the expression of a diverse set of genes. The toxicity of the potent AhR ligand 2,3,7,8-tetrachlorodibenzo-p-dioxin is almost exclusively mediated through this receptor. However, the key alterations in gene expression that mediate toxicity are poorly understood. It has been established through characterization of AhR-null mice that the AhR has a required physiological function, yet how endogenous mediators regulate this orphan receptor remains to be established. A picture as to how the AhR/ARNT heterodimer actually mediates gene transcription is starting to emerge. The AhR/ARNT complex can alter transcription both by binding to its cognate response element and through tethering to other transcription factors. In addition, many of the coregulatory proteins necessary for AhR-mediated transcription have been identified. Cross talk between the estrogen receptor and the AhR at the promoter of target genes appears to be an important mode of regulation. Inflammatory signaling pathways and the AhR also appear to be another important site of cross talk at the level of transcription. A major focus of this review is to highlight experimental efforts to characterize nonclassical mechanisms of AhR-mediated modulation of gene transcription.

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  495. Morales-Prieto Noelia, Abril Nieves, REDOX proteomics reveals energy metabolism alterations in the liver of M. spretus mice exposed to p, p′-DDE, Chemosphere, 186, 2017. Crossref

  496. Liu Ge, Asanoma Kazuo, Takao Tomoka, Tsukimori Kiyomi, Uchi Hiroshi, Furue Masutaka, Kato Kiyoko, Wake Norio, Aryl hydrocarbon receptor SNP –130 C/T associates with dioxins susceptibility through regulating its receptor activity and downstream effectors including interleukin 24, Toxicology Letters, 232, 2, 2015. Crossref

  497. Dar Owias Iqbal, Aslam Raouf, Pan Deng, Sharma Sunil, Andotra Megha, Kaur Arvinder, Jia Ai-Qun, Faggio Caterina, Source, bioaccumulation, degradability and toxicity of triclosan in aquatic environments: A review, Environmental Technology & Innovation, 25, 2022. Crossref

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