Library Subscription: Guest
Begell Digital Portal Begell Digital Library eBooks Journals References & Proceedings Research Collections
Critical Reviews™ in Eukaryotic Gene Expression
IF: 1.734 5-Year IF: 1.848 SJR: 0.627 SNIP: 0.516 CiteScore™: 1.96

ISSN Print: 1045-4403
ISSN Online: 2162-6502

Critical Reviews™ in Eukaryotic Gene Expression

DOI: 10.1615/CritRevEukarGeneExpr.v21.i2.60
pages 177-185

The Role of BMP2 Signaling in the Skeleton

Jonathan W. Lowery
Department of Developmental Biology, Harvard School of Dental Medicine, Boston, MA, USA
Dorothy Pazin
Department of Developmental Biology, Harvard School of Dental Medicine, Boston, MA, USA
Giuseppe Intini
Department of Developmental Biology, Harvard School of Dental Medicine, Boston, MA, USA
Shoichiro Kokabu
Department of Developmental Biology, Harvard School of Dental Medicine, Boston, MA, USA
Vivianne Chappuis
Department of Developmental Biology, Harvard School of Dental Medicine, Boston, MA, USA
Luciane P. Capelo
Department of Developmental Biology, Harvard School of Dental Medicine, Boston, MA, USA
Vicki Rosen
Harvard University

ABSTRACT

While new roles for the adult skeleton as an endocrine organ continue to emerge, our understanding of how bone homeostasis is maintained is also changing. Here we focus on BMP2, a molecule identified by its ability to induce bone formation at extraskeletal sites. We detail specific roles for BMP2 in the adult skeleton, where it acts to regulate the differentiation of periosteal skeletal progenitors during fracture healing and also mediates osteoblast formation in the bone marrow microenvironment. We highlight two areas of BMP2 biology that deserve further study: the specific signaling pathways used by BMP2 to affect bone formation, and the factors that regulate BMP2 production in the adult skeleton. These activities serve to distinguish BMP2 from other members of the TGF-b/BMP/Activin gene superfamily.