Library Subscription: Guest
Critical Reviews™ in Eukaryotic Gene Expression

Published 6 issues per year

ISSN Print: 1045-4403

ISSN Online: 2162-6502

The Impact Factor measures the average number of citations received in a particular year by papers published in the journal during the two preceding years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) IF: 1.6 To calculate the five year Impact Factor, citations are counted in 2017 to the previous five years and divided by the source items published in the previous five years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) 5-Year IF: 2.2 The Immediacy Index is the average number of times an article is cited in the year it is published. The journal Immediacy Index indicates how quickly articles in a journal are cited. Immediacy Index: 0.3 The Eigenfactor score, developed by Jevin West and Carl Bergstrom at the University of Washington, is a rating of the total importance of a scientific journal. Journals are rated according to the number of incoming citations, with citations from highly ranked journals weighted to make a larger contribution to the eigenfactor than those from poorly ranked journals. Eigenfactor: 0.00058 The Journal Citation Indicator (JCI) is a single measurement of the field-normalized citation impact of journals in the Web of Science Core Collection across disciplines. The key words here are that the metric is normalized and cross-disciplinary. JCI: 0.33 SJR: 0.345 SNIP: 0.46 CiteScore™:: 2.5 H-Index: 67

Indexed in

Peroxisome Proliferator-Activated Receptor Alpha (PPARα), a Key Regulator of Lipid Metabolism in Avians

Volume 26, Issue 4, 2016, pp. 303-308
DOI: 10.1615/CritRevEukaryotGeneExpr.2016016665
Get accessGet access

ABSTRACT

Dietary fatty acids have various effects on cellular metabolism, and many of these effects are carried out through the alteration of the gene expression. Fatty acids upregulate or downregulate the expression of different genes by acting both as agonists or antagonists for nuclear hormone receptors. Peroxisome proliferator-activated receptors (PPARs) are members of the nuclear hormone receptor superfamily. To date, three PPAR subtypes, α, β, and γ, have been recognized. PPARs regulate various target genes with a role in intracellular and extracellular lipid metabolism, mainly those involved in peroxisomal β-oxidation. PPAR controls several genes involved in lipid metabolism, including Δ-5, Δ-6, and Δ-9 desaturases, acyl-coenzyme A oxidase, and carnitine palmitoyltransferase. The activation of PPARα might thus decrease fat deposits indirectly by raising hepatic fatty acid β-oxidation. PPARα is likely part of the regulating system of energy metabolism in peripheral tissues such as adipose tissue and skeletal muscles.

CITED BY
  1. Zhao Meng, Jiang Qixiao, Geng Min, Zhu Li, Xia Yunqiu, Khanal Aashish, Wang Chunbo, The role of PPAR alpha in perfluorooctanoic acid induced developmental cardiotoxicity and l-carnitine mediated protection–Results of in ovo gene silencing, Environmental Toxicology and Pharmacology, 56, 2017. Crossref

  2. Zhu Ke-Cheng, Song Ling, Guo Hua-Yang, Guo Liang, Zhang Nan, Liu Bao-Suo, Jiang Shi-Gui, Zhang Dian-Chang, Identification of Fatty Acid Desaturase 6 in Golden Pompano Trachinotus Ovatus (Linnaeus 1758) and Its Regulation by the PPARαb Transcription Factor, International Journal of Molecular Sciences, 20, 1, 2018. Crossref

  3. Zhu Ke-Cheng, Song Ling, Guo Hua-Yang, Guo Liang, Zhang Nan, Liu Bao-Suo, Jiang Shi-Gui, Zhang Dian-Chang, Elovl4a participates in LC-PUFA biosynthesis and is regulated by PPARαβ in golden pompano Trachinotus ovatus (Linnaeus 1758), Scientific Reports, 9, 1, 2019. Crossref

  4. Zhu Ke-Cheng, Zhang Nan, Liu Bao-Suo, Guo Liang, Guo Hua-Yang, Jiang Shi-Gui, Zhang Dian-Chang, Transcription factor pparαb activates fads2s to promote LC-PUFA biosynthesis in the golden pompano Trachinotus ovatus (Linnaeus 1758), International Journal of Biological Macromolecules, 161, 2020. Crossref

  5. Wang Hongwu, Wu Ting, Wang Yaqi, Wan Xiaoyang, Qi Junying, Li Lan, Wang Xiaojing, Luo Xiaoping, Ning Qin, Regulatory T cells suppress excessive lipid accumulation in alcoholic liver disease, Journal of Lipid Research, 60, 5, 2019. Crossref

  6. Medina Martinez Oscar David, Vieira Theodoro Jaqueline Maciel, Grancieri Mariana, Lopes Toledo Renata Celi, Vieira Queiroz Valéria Aparecida, Ribeiro de Barros Frederico Augusto, Duarte Martino Hércia Stampini, Dry heated whole sorghum flour (BRS 305) with high tannin and resistant starch improves glucose metabolism, modulates adiposity, and reduces liver steatosis and lipogenesis in Wistar rats fed with a high-fat high-fructose diet, Journal of Cereal Science, 99, 2021. Crossref

  7. Li Baicheng, Li Jia, Hu Shuwen, Cinnamon could improve hepatic steatosis caused by a high‐fat diet via enhancing hepatic beta‐oxidation and inhibiting hepatic lipogenesis, oxidative damage, and inflammation in male rats, Journal of Food Biochemistry, 46, 6, 2022. Crossref

Forthcoming Articles

PRMT6 promotes the immune evasion of gastric cancer via upregulating ANXA1 Liang Xu, Fenger Zhang, Binqi Yu, Shengnan Jia, Sunfu Fan PURPL promotes M2 macrophage polarization in lung cancer via regulating RBM4/xCT signaling Jipeng Guo, Chongwen Gong, Hao Wang SIAH1 promotes the pyroptosis of cardiomyocytes in diabetic cardiomyopathy via regulating IκB-α/NF-κB signaling Jinbin Wu, Yaoming Yan SLC7A2-mediated lysine catabolism inhibits immunosuppression in triple negative breast cancer Yuanyuan Sun, Yaqing Li, Chengying Jiang, Chenying Liu, Yuanming Song SIAH2-mediated degradation of ACSL4 inhibits the anti-tumor activity of CD8+ T cells in hepatocellular carcinoma Fangzheng Shu, Yuhua Shi, Xiangxiang Shan, Wenzhang Zha, Rengen Fan, Wanjiang Xue RBM15-mediated N6-methyl adenosine (m6A) modification of EZH2 drives the epithelial-mesenchymal transition of cervical cancer Ruixue Wang, Wenhua Tan Evidence-Based Storytelling and A Strategic Roadmap to Promote Cancer Prevention Via Adolescent HPV Vaccination in Northern New England Matthew Dugan, Gary Stein, Jan Carney, Sheila Clifford-Bova KDM4A-AS1 promotes cell proliferation, migration and invasion via the miR-4306/STX6 axis in hepatocellular carcinoma Wei Cao, Yuhan Ren, Ying Liu, Guoshu Cao, Zhen Chen, Fan Wang HDAC1-mediated downregulation of NEU1 exacerbates the aggressiveness of cervical cancer Nanzi Xie, Sisi Mei, Changlan Dai, Wei Chen Effect of miR-26b-5p on progression of acute myeloid leukemia by regulating USP48-mediated Wnt/β-catenin pathway Yu Xie, Lin Tan, Kun Wu, Deyun Li, Chengping Li
Begell Digital Portal Begell Digital Library eBooks Journals References & Proceedings Research Collections Prices and Subscription Policies Begell House Contact Us Language English 中文 Русский Português German French Spain