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Critical Reviews™ in Eukaryotic Gene Expression
IF: 1.734 5-Year IF: 1.848 SJR: 0.627 SNIP: 0.516 CiteScore™: 1.96

ISSN Print: 1045-4403
ISSN Online: 2162-6502

Critical Reviews™ in Eukaryotic Gene Expression

DOI: 10.1615/CritRevEukaryotGeneExpr.2017019193
pages 113-150

Ethnopharmacological Investigations of Phytochemical Constituents Isolated from the Genus Cuscuta

Muhammad Ibrahim
Department of Applied Chemistry, Government College University Faisalabad, Pakistan
Kanwal Rehman
Institute of Pharmacy, Physiology and Pharmacology, University of Agriculture, Faisalabad, Pakistan
Iqbal Hussain
Department of Environmental Life Sciences, Graduate School of Life Sciences, Tohoku University, Sendai 980-8579 Japan; Department of Botany, Government College University, Faisalabad, Pakistan
Tahir Farooq
Department of Applied Chemistry, Government College University, Faisalabad, Pakistan
Bisharat Ali
Department of Applied Chemistry, Government College University, Faisalabad, Pakistan
Irum Majeed
Department of Applied Chemistry, Government College University, Faisalabad, Pakistan
Muhammad Sajid Hamid Akash
Department of Pharmaceutical Chemistry, Government College University Faisalabad, Pakistan

ABSTRACT

The genus Cuscuta, of the family Cuscutaceae, is present in plants and has been traditionally used medicinally against many diseases and conditions, notably depression, mental illness, headache, spleen disease, jaundice, diabetes mellitus, and hypertension. Large numbers of phytochemical constituents such as alkaloids, flavonoids, lignins, oxygen heterocyclic compounds, steroids, fatty acids, phenolic acids, resin glycosides, and polysaccharides have been isolated from different species of Cuscuta. Ethnopharmacological studies conducted on such constituents have also been shown Cuscuta to possess anticancer, antiviral, antispasmodic, antihypertensive, anticonvulsant, antibacterial, antioxidant, diuretic, and hair-growth activity. Many tribes and traditional communities have long used the different forms of Cuscuta for treatment and prevention of many diseases. In this article, we comprehensively summarize relevant data regarding the phytochemical, ethnopharmacological, and traditional therapeutic uses of Cuscuta. In addition, we review the parts of the plants that are used as traditional therapeutic agents, their regions of existence, and their possible modes of action. To conclude, we provide evidence and new insights for further discovery and development of natural drugs from Cuscuta. We show that further studies are needed to investigate the mechanism of action and safety profile of phytochemical constituents isolated from Cuscuta.