Library Subscription: Guest
Begell Digital Portal Begell Digital Library eBooks Journals References & Proceedings Research Collections
Critical Reviews™ in Eukaryotic Gene Expression
IF: 2.156 5-Year IF: 2.255 SJR: 0.649 SNIP: 0.599 CiteScore™: 3

ISSN Print: 1045-4403
ISSN Online: 2162-6502

Critical Reviews™ in Eukaryotic Gene Expression

DOI: 10.1615/CritRevEukarGeneExpr.v9.i3-4.130
pages 285-293

The Nuclear Lamina: Molecular Organization and Interaction with Chromatin

Michal Goldberg
Department of Genetics, The Institute of Life Sciences, The Hebrew University of Jerusalem, Jerusalem 91904, Israel
Amnon Harel
Department of Biology, University of California at San Diego, La Jolla, California, USA
Yosef Gruenbaum
Department of Genetics, The Institute of Life Sciences, The Hebrew University of Jerusalem, Jerusalem 91904, Israel

ABSTRACT

The nuclear lamina is located between the inner nuclear membrane and the peripheral chromatin. It is composed mainly of nuclear lamins and lamina-associated proteins. The nuclear lamina is involved in nuclear organization, cell cycle regulation, and differentiation. As such, impairment in its architecture and/or function leads to genetic diseases and apoptosis. This article describes the molecular organization of the nuclear lamins, their assembly into filaments, their distribution within the nucleus, and the complex network of interactions between them and other proteins of the inner nuclear membrane. Recent findings unraveled evidence for specific interactions between proteins of the nuclear lamina and the chromatin. These include interactions between nuclear lamins and core histones, Lamina Associated Polypeptide 2 (LAP2), and the Barrier to Autointegration Factor (BAF) and interactions between lamin B receptor (LBR) and the chromodomain protein HP1. Taken together, these studies attribute a role for both the nuclear lamins and the lamina-associated proteins, LAP2 and LBR, in nuclear organization and nuclear assembly.


Articles with similar content:

Lamins and Lamin-Binding Proteins in Functional Chromatin Organization
Critical Reviews™ in Eukaryotic Gene Expression, Vol.9, 1999, issue 3-4
Josef Gotzmann , Roland Foisner
Vitamin D and MicroRNAs in Bone
Critical Reviews™ in Eukaryotic Gene Expression, Vol.23, 2013, issue 3
Martin Hewison, John S. Adams, Thomas S. Lisse
Nuclear Domains Involved in RNA Synthesis, RNA Processing, and Replication
Critical Reviews™ in Eukaryotic Gene Expression, Vol.6, 1996, issue 2-3
Luitzen de Jong, Karin A. Mattern, Marjolein A. Grande, Roel van Driel, Wouter Schul
Long-Term Effects of Chromatin Remodeling and DNA Damage in Stem Cells Induced by Environmental and Dietary Agents
Journal of Environmental Pathology, Toxicology and Oncology, Vol.32, 2013, issue 4
C. Greer Vestal, Christine Richardson, Bhawana Bariar
Regulatory Roles of Rpl22 in Hematopoiesis: An Old Dog with New Tricks
Critical Reviews™ in Immunology, Vol.35, 2015, issue 5
Shawn P. Fahl, Yong Zhang, Anne-Cecile E. Duc, David L. Wiest, Minshi Wang