Library Subscription: Guest
Critical Reviews™ in Eukaryotic Gene Expression

Published 6 issues per year

ISSN Print: 1045-4403

ISSN Online: 2162-6502

The Impact Factor measures the average number of citations received in a particular year by papers published in the journal during the two preceding years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) IF: 1.6 To calculate the five year Impact Factor, citations are counted in 2017 to the previous five years and divided by the source items published in the previous five years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) 5-Year IF: 2.2 The Immediacy Index is the average number of times an article is cited in the year it is published. The journal Immediacy Index indicates how quickly articles in a journal are cited. Immediacy Index: 0.3 The Eigenfactor score, developed by Jevin West and Carl Bergstrom at the University of Washington, is a rating of the total importance of a scientific journal. Journals are rated according to the number of incoming citations, with citations from highly ranked journals weighted to make a larger contribution to the eigenfactor than those from poorly ranked journals. Eigenfactor: 0.00058 The Journal Citation Indicator (JCI) is a single measurement of the field-normalized citation impact of journals in the Web of Science Core Collection across disciplines. The key words here are that the metric is normalized and cross-disciplinary. JCI: 0.33 SJR: 0.345 SNIP: 0.46 CiteScore™:: 2.5 H-Index: 67

Indexed in

Functional Links between Nuclear Structure, Gene Expression, DNA Replication, and Methylation

Volume 9, Issue 3-4, 1999, pp. 345-351
DOI: 10.1615/CritRevEukarGeneExpr.v9.i3-4.190
Get accessGet access

ABSTRACT

Over the last decades it became clear that mammalian nuclei are highly organized. Nuclear processes like DNA replication and RNA metabolism take place in distinct subnuclear foci, which are enriched for enzymes involved in the corresponding biochemical reactions. This colocalization of functions with their respective factors is often referred to as functional organization of the nucleus. This organization is achieved by assembly of different enzymes and regulatory factors into high-molecular-weight complexes that are tethered to insoluble nuclear structures. Recently, several links between nuclear structure, gene expression, DNA replication, and methylation have been described that illustrate the interrelation of higher-order structures and nuclear functions. New insights into the functional organization of the nucleus and how it could explain the high precision and overall coordination of nuclear processes are discussed.

CITED BY
  1. Ostrow Kimberly, Michailidi Christina, Guerrero-Preston Rafael, Hoque Mohammad, Greenberg Alissa, Rom William, Sidransky David, Cigarette smoke induces methylation of the tumor suppressor geneNISCH, Epigenetics, 8, 4, 2013. Crossref

  2. Cheng Jinping, Fernando K. A. Shiral, Veca L. Monica, Sun Ya-Ping, Lamond Angus I., Lam Yun Wah, Cheng Shuk Han, Reversible Accumulation of PEGylated Single-Walled Carbon Nanotubes in the Mammalian Nucleus, ACS Nano, 2, 10, 2008. Crossref

  3. van Zandvoort Marc A.M.J., de Grauw Cees J., Gerritsen Hans C., Broers Jos L.V., oude Egbrink Mirjam G.A., Ramaekers Frans C.S., Slaaf Dick W., Discrimination of DNA and RNA in cells by a vital fluorescent probe: Lifetime imaging of SYTO13 in healthy and apoptotic cells, Cytometry, 47, 4, 2002. Crossref

  4. Kim Seok-Ho, Kang Yong-Kook, Koo Deog-Bon, Kang Man-Jong, Moon Seung-Ju, Lee Kyung-Kwang, Han Yong-Mahn, Differential DNA methylation reprogramming of various repetitive sequences in mouse preimplantation embryos, Biochemical and Biophysical Research Communications, 324, 1, 2004. Crossref

  5. Grünwald David, Martin Robert M., Buschmann Volker, Bazett-Jones David P., Leonhardt Heinrich, Kubitscheck Ulrich, Cardoso M. Cristina, Probing Intranuclear Environments at the Single-Molecule Level, Biophysical Journal, 94, 7, 2008. Crossref

  6. Cardoso M Cristina, Schneider Katrin, Martin Robert M, Leonhardt Heinrich, Structure, function and dynamics of nuclear subcompartments, Current Opinion in Cell Biology, 24, 1, 2012. Crossref

  7. Niki Takeshi, Galli Ivo, Ariga Hiroyoshi, Iguchi-Ariga Sanae M.M., MSSP, a protein binding to an origin of replication in the c-myc gene, interacts with a catalytic subunit of DNA polymerase α and stimulates its polymerase activity, FEBS Letters, 475, 3, 2000. Crossref

  8. Takayama Masa-aki, Taira Takahiro, Iguchi-Ariga Sanae M.M., Ariga Hiroyoshi, CDC6 interacts with c-Myc to inhibit E-box-dependent transcription by abrogating c-Myc/Max complex, FEBS Letters, 477, 1-2, 2000. Crossref

  9. LI DONG, YANG ZHENG-KAI, BU JING-YI, XU CHUN-YAN, SUN HUI, TANG JIE-BING, LIN PING, CHENG WEN, HUANG NING, CUI RONG-JUN, YU XIAO-GUANG, ZHENG XIU-LAN, OCT4B modulates OCT4A expression as ceRNA in tumor cells, Oncology Reports, 33, 5, 2015. Crossref

  10. Ngo Thuy T. M., Yoo Jejoong, Dai Qing, Zhang Qiucen, He Chuan, Aksimentiev Aleksei, Ha Taekjip, Effects of cytosine modifications on DNA flexibility and nucleosome mechanical stability, Nature Communications, 7, 1, 2016. Crossref

  11. Anglana Mauro, Debatisse Michelle, Dual Control of Replication Timing, Journal of Biological Chemistry, 276, 39, 2001. Crossref

  12. Micura Ronald, Pils Werner, Höbartner Claudia, Grubmayr Karl, Ebert Marc-Olivier, Jaun Bernhard, Methylation of the nucleobases in RNA oligonucleotides mediates duplex–hairpin conversion, Nucleic Acids Research, 29, 19, 2001. Crossref

  13. Herrmann Markus, Schorr Heike, Obeid Rima, Scharhag Jürgen, Urhausen Axel, Kindermann Wilfried, Herrmann Wolfgang, Homocysteine Increases during Endurance Exercise, Clinical Chemistry and Laboratory Medicine, 41, 11, 2003. Crossref

  14. Welcome Menizibeya Osain, Cellular Organization of the Gastrointestinal Tract, in Gastrointestinal Physiology, 2018. Crossref

  15. Michael Kirschenbaum, Serge Ankri, Entamoeba histolytica: Bridging the Gap Between Environmental Stress and Epigenetic Regulation, in Amebiasis, 2015. Crossref

  16. Kennedy Brian K., Barbie David A., Classon Marie, Dyson Nicholas, Harlow Ed, Nuclear organization of DNA replication in primary mammalian cells, Genes & Development, 14, 22, 2000. Crossref

  17. Hoque Mohammad Obaidul, Kim Myoung Sook, Ostrow Kimberly Laskie, Liu Junwei, Wisman G. Bea A., Park Hannah Lui, Poeta Maria Luana, Jeronimo Carmen, Henrique Rui, Lendvai Ágnes, Schuuring Ed, Begum Shahnaz, Rosenbaum Eli, Ongenaert Maté, Yamashita Keishi, Califano Joseph, Westra William, van der Zee Ate G.J., Criekinge Wim Van, Sidransky David, Genome-Wide Promoter Analysis Uncovers Portions of the Cancer Methylome, Cancer Research, 68, 8, 2008. Crossref

  18. Brait Mariana, Begum Shahnaz, Carvalho André L., Dasgupta Santanu, Vettore André L., Czerniak Bogdan, Caballero Otávia L., Westra William H., Sidransky David, Hoque Mohammad Obaidul, Aberrant Promoter Methylation of Multiple Genes during Pathogenesis of Bladder Cancer, Cancer Epidemiology, Biomarkers & Prevention, 17, 10, 2008. Crossref

  19. Abramov Gili, Velyvis Algirdas, Rennella Enrico, Wong Leo E., Kay Lewis E., A methyl-TROSY approach for NMR studies of high-molecular-weight DNA with application to the nucleosome core particle, Proceedings of the National Academy of Sciences, 117, 23, 2020. Crossref

Forthcoming Articles

PRMT6 promotes the immune evasion of gastric cancer via upregulating ANXA1 Liang Xu, Fenger Zhang, Binqi Yu, Shengnan Jia, Sunfu Fan PURPL promotes M2 macrophage polarization in lung cancer via regulating RBM4/xCT signaling Jipeng Guo, Chongwen Gong, Hao Wang SIAH1 promotes the pyroptosis of cardiomyocytes in diabetic cardiomyopathy via regulating IκB-α/NF-κB signaling Jinbin Wu, Yaoming Yan SLC7A2-mediated lysine catabolism inhibits immunosuppression in triple negative breast cancer Yuanyuan Sun, Yaqing Li, Chengying Jiang, Chenying Liu, Yuanming Song SIAH2-mediated degradation of ACSL4 inhibits the anti-tumor activity of CD8+ T cells in hepatocellular carcinoma Fangzheng Shu, Yuhua Shi, Xiangxiang Shan, Wenzhang Zha, Rengen Fan, Wanjiang Xue RBM15-mediated N6-methyl adenosine (m6A) modification of EZH2 drives the epithelial-mesenchymal transition of cervical cancer Ruixue Wang, Wenhua Tan Evidence-Based Storytelling and A Strategic Roadmap to Promote Cancer Prevention Via Adolescent HPV Vaccination in Northern New England Matthew Dugan, Gary Stein, Jan Carney, Sheila Clifford-Bova KDM4A-AS1 promotes cell proliferation, migration and invasion via the miR-4306/STX6 axis in hepatocellular carcinoma Wei Cao, Yuhan Ren, Ying Liu, Guoshu Cao, Zhen Chen, Fan Wang HDAC1-mediated downregulation of NEU1 exacerbates the aggressiveness of cervical cancer Nanzi Xie, Sisi Mei, Changlan Dai, Wei Chen Effect of miR-26b-5p on progression of acute myeloid leukemia by regulating USP48-mediated Wnt/β-catenin pathway Yu Xie, Lin Tan, Kun Wu, Deyun Li, Chengping Li
Begell Digital Portal Begell Digital Library eBooks Journals References & Proceedings Research Collections Prices and Subscription Policies Begell House Contact Us Language English 中文 Русский Português German French Spain