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Critical Reviews™ in Eukaryotic Gene Expression

Published 6 issues per year

ISSN Print: 1045-4403

ISSN Online: 2162-6502

The Impact Factor measures the average number of citations received in a particular year by papers published in the journal during the two preceding years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) IF: 1.6 To calculate the five year Impact Factor, citations are counted in 2017 to the previous five years and divided by the source items published in the previous five years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) 5-Year IF: 2.2 The Immediacy Index is the average number of times an article is cited in the year it is published. The journal Immediacy Index indicates how quickly articles in a journal are cited. Immediacy Index: 0.3 The Eigenfactor score, developed by Jevin West and Carl Bergstrom at the University of Washington, is a rating of the total importance of a scientific journal. Journals are rated according to the number of incoming citations, with citations from highly ranked journals weighted to make a larger contribution to the eigenfactor than those from poorly ranked journals. Eigenfactor: 0.00058 The Journal Citation Indicator (JCI) is a single measurement of the field-normalized citation impact of journals in the Web of Science Core Collection across disciplines. The key words here are that the metric is normalized and cross-disciplinary. JCI: 0.33 SJR: 0.345 SNIP: 0.46 CiteScore™:: 2.5 H-Index: 67

Indexed in

lep Expression and Its Role in Obesity and Type-2 Diabetes

Volume 27, Issue 1, 2017, pp. 47-51
DOI: 10.1615/CritRevEukaryotGeneExpr.2017019386
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ABSTRACT

Obesity is metabolic disorder that increases the risk of diabetes, heart disease, and other metabolic syndromes in human beings. One sign of diabetes is increased blood glucose levels in the body. Glucose levels increase due to problems with insulin secretion or insulin resistance. Maturity onset of diabetes of the young is more common in adults and occurs due to insulin resistance. Both diabetes and obesity are major problems that are responsible for the death of millions of individuals every year, worldwide. Leptin, a 164-KDa hormone that is secreted by white adipose tissue, is a product of the lep gene. Mutation in lep decreases leptin concentration and increases obesity and type-2 diabetes mellitus. Leptin has been shown to produce positive effects on hunger, energy expenditure, and behavior and is thus useful in the treatment of obesity and type-2 diabetes. Leptin controls appetite through its effect on the hypothalamus in the brain. Both leptin and insulin regulate appetite, body weight, and glucose levels in the body.

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  2. Liu Wei, Zhou Xianghai, Li Yufeng, Zhang Simin, Cai Xiaoling, Zhang Rui, Gong Siqian, Han Xueyao, Ji Linong, Serum leptin, resistin, and adiponectin levels in obese and non-obese patients with newly diagnosed type 2 diabetes mellitus, Medicine, 99, 6, 2020. Crossref

  3. Noreen Zarish, Loffredo Christopher A., Bhatti Attya, Simhadri Jyothirmai J., Nunlee-Bland Gail, Nnanabu Thomas, John Peter, Khan Jahangir S., Ghosh Somiranjan, Transcriptional Profiling and Biological Pathway(s) Analysis of Type 2 Diabetes Mellitus in a Pakistani Population, International Journal of Environmental Research and Public Health, 17, 16, 2020. Crossref

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  5. Sorokina Yu. A., Zanozina O. V., Makarova E. V., Salcev S. G., Varvarina G. N., Lovtsova L. V., Leptin and its receptor gene polymorphism as a target for pharmacotherapy in T2DM and COPD, Meditsinskiy sovet = Medical Council, 7, 2021. Crossref

  6. Yoldemir Sengul Aydin, Arman Yucel, Akarsu Murat, Altun Ozgur, Ozcan Mustafa, Tukek Tufan, Correlation of glycemic regulation and endotrophin in patients with type 2 Diabetes; pilot study, Diabetology & Metabolic Syndrome, 13, 1, 2021. Crossref

  7. Mir Mohammad Muzaffar, Mir Rashid, Alghamdi Mushabab Ayed Abdullah, Wani Javed Iqbal, Sabah Zia Ul, Jeelani Mohammed, Marakala Vijaya, Sohail Shahzada Khalid, O’haj Mohamed, Alharthi Muffarah Hamid, Alamri Mohannad Mohammad S., Differential Association of Selected Adipocytokines, Adiponectin, Leptin, Resistin, Visfatin and Chemerin, with the Pathogenesis and Progression of Type 2 Diabetes Mellitus (T2DM) in the Asir Region of Saudi Arabia: A Case Control Study, Journal of Personalized Medicine, 12, 5, 2022. Crossref

  8. Wang Yunzhe, Zhang Chenyang, Wang Yuxiang, Liu Xiuping, Zhang Zhao, Enhancer RNA (eRNA) in Human Diseases, International Journal of Molecular Sciences, 23, 19, 2022. Crossref

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