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Critical Reviews™ in Eukaryotic Gene Expression
IF: 2.156 5-Year IF: 2.255 SJR: 0.649 SNIP: 0.599 CiteScore™: 3

ISSN Print: 1045-4403
ISSN Online: 2162-6502

Critical Reviews™ in Eukaryotic Gene Expression

DOI: 10.1615/CritRevEukaryotGeneExpr.2020028454
pages 291-297

Malignant Melanoma: Skin Cancer−Diagnosis, Prevention, and Treatment

Bilal Ahmed
School of Pharmacy, Nanjing Medical University, Nanjing, Jiangsu Province, PR China
Muhammad Imran Qadir
Institute of Molecular Biology and Biotechnology, Bahauddin Zakariya University, Multan, Pakistan
Saba Ghafoor
Institute of Molecular Biology & Biotechnology, Bahauddin Zakariya University, Multan, Pakistan


Melanoma is a skin cancer caused by a malignancy of melanocytes. Incidence of melanoma is rapidly increasing worldwide, which results in public health problems. Primary extracutaneous melanomas can be ocular, gastrointestinal, mucosal, leptomeningeal, genitourinary, and lymphatic. The relationship between exposure to ultraviolet (UV) light and development of melanoma is intensively acute and complex, and intermittent sun exposure greatly increases the risk of melanoma. It is the fifth most common type of cancer in men number and the sixth most common in women. The diagnosis of melanoma is made through clinical assessment of the pigmented by health care professionals. Architectural features of malignant melanoma including asymmetry, confluence of growth, marked cellularity, and poor circumscription. The cytological feature of malignant melanoma include an irregular and thick nuclear membrane and prominent nucleoli. The preventive measures include reducing exposure to UV light and the sun. The early detection of skin cancer greatly reduces both short- and long-term morbidity and mortality. The treatment and follow-up with the doctor for melanoma patients may differ because of the stage of the tumor and the primary lesion. The typical therapy for malignant melanoma is surgical excision, immunotherapy such as interleukin 2 (IL-2), gene therapy, and biochemotherapy.


  1. Bloomston M, Frankel WL, Petrocca F, Volinia S, Alder H, Hagan JP, Liu C-G, Bhatt D, Taccioli C, Croce CM. MicroRNA expression patterns to differentiate pancreatic adenocarcinoma from normal pancreas and chronic pancreatitis. JAMA. 2007;297(17):1901-8.

  2. Jemal A, Devesa SS, Hartge P, Tucker MA. Recent trends in cutaneous melanoma incidence among whites in the United States. J Natl Cancer Inst. 2001;93(9):678-83.

  3. Edwards BK, Howe HL, Ries LAG, Thun MJ, Rosenberg HM, Yancik R, Wingo PA, Jemal A, Feigal EG. Annual report to the nation on the status of cancer, 1973-1999, featuring implications of age and aging on U.S. cancer burden. Cancer. 2002;94(10):2766-92.

  4. Elwood JM, Gallagher RP. Site distribution of malignant melanoma. Canadian Med Asso J. 1983;128(12):1400.

  5. Rigel DS. Malignant melanoma. CA Cancer J Clin. 2000;50(4):215-36.

  6. Robinson MR, Chan C-C, Yang JC, Rubin BI, Gracia GJ, Sen HN, Csaky KG, Rosenberg SA. Cytotoxic T lymphocyte-associated antigen 4 blockade in patients with meta-static melanoma: A new cause of uveitis. J Immunother. 2004;27(6):478-9.

  7. Abbasi NR, Shaw HM, Rigel DS, Friedman RJ, McCarthy WH, Osman I, Kopf AW, Polsky D. Early diagnosis of cutaneous melanoma: Revisiting the ABCD criteria. JAMA. 2004;292(22):2771-6.

  8. Markovic SN, Erickson LA, Rao RD, Weenig RH, Pockaj BA, Bardia A, Vachon CM, Schild SE, McWilliams RR, Hand JL, Laman SD, Kottschade LA, Maples WJ, Pittelkow MR, Pulido JS, Cameron JD, Creagan ET, Melanoma Study Group of the Mayo Clinic Cancer Center. Malignant melanoma in the 21st century, part 1: Epidemiology, risk factors, screening, prevention, and diagnosis. Mayo Clin Proc. 2007;82(3):364-80.

  9. Gonzalez A, West AJ, Pitha JV, Taira JW. Small-diameter invasive melanomas: Clinical and pathologic characteristics. J Cutan Pathol. 1996;23(2):126-32.

  10. Kamino H, Kiryu H, Ratech H. Small malignant melanomas: Clinicopathologic correlation and DNA ploidy analysis. J Am Acad Dermatol. 1990;22(6):1032-8.

  11. McNutt NS, Urmacher C, Hakimian J, Hoss DM, Lugo J. Nevoid malignant melanoma: Morphologic patterns and immunohistochemical reactivity. J Cutan Pathol. 1995;22(6):502-17.

  12. Balch CM. Cutaneous melanoma: Prognosis and treatment results worldwide. Semin Surg Oncol. 1992;8(6):400-14.

  13. Cascinelli N, Zurrida S, Galimberti V, Bartoli C, Bufalino R, Del Prato I, Mascheroni L, Testori A, Clemente C. Acral lentiginous melanoma. A histological type without prognostic significance. J Dermatol Surg Oncol. 1994;20(12):817-22.

  14. Chang AE, Karnell LH, Menck HR. The National Cancer Data Base report on cutaneous and noncutaneous melanoma. A summary of 84,836 cases from the past decade. The American College of Surgeons Commission on Cancer and the American Cancer Society. Cancer. 1998;83(8):1664-78.

  15. Newell GR, Sider JG, Bergfelt L, Kripke ML. Incidence of cutaneous melanoma in the United States by histology with special reference to the face. Cancer Res. 1988;48(17):5036-41.

  16. Cox NH, Aitchison TC, Sirel JM, MacKie RM. Comparison between lentigo maligna melanoma and other histogenetic types of malignant melanoma of the head and neck. Br J Cancer. 1996;73(7):940-4.

  17. Clark WH Jr, Elder DE, Guerry D 4th, Braitman LE, Trock BJ, Schultz D, Synnestvedt M, Halpern AC. Model predicting survival in stage I melanoma based on tumor progression. J Natl Cancer Inst. 1989;81(24):1893-904.

  18. Crowson AN, Magro CM, Mihm MC Jr. The melanocytic proliferations: A comprehensive textbook of pigmented lesions. Hoboken, NJ: John Wiley & Sons; 2001.

  19. Barnhill RL, Piepkorn M, Busam KJ. Pathology of melanocytic nevi and malignant melanoma. New York: Springer Science & Business Media; 2014.

  20. Kaskel P, Sander S, Kron M, Kind P, Peter RU, Krahn G. Outdoor activities in childhood: A protective factor for cutaneous melanoma? Results of a case-control study in 271 matched pairs. Br J Dermatol. 2001;145(4):602-9.

  21. Grob JJ, Guglielmina C, Gouvernet J, Zarour H, Noe C, Bonerandi JJ. Study of sunbathing habits in children and adolescents: Application to the prevention of melanoma. Dermatology. 1993;186(2):94-8.

  22. Montague M, Borland R, Sinclair C. Slip! Slop! Slap! and Sun Smart, 1980-2000: Skin cancer control and 20 years of population-based campaigning. Health Educ Behav. 2001;28(3):290-305.

  23. Aitken JF, Janda M, Elwood M, Youl PH, Ring IT, Lowe JB. Clinical outcomes from skin screening clinics within a community-based melanoma screening program. J Am Acad Dermatol. 2006;54(1):105-14.

  24. Marks R. An overview of skin cancers. Incidence and causation. Cancer. 1995;75(2 Suppl):607-12.

  25. Qadir MI. Skin cancer: Etiology and management. Pak J Pharm Sci. 2016;29(3):999-1003.

  26. Rigel DS, Carucci JA. Malignant melanoma: prevention, early detection, and treatment in the 21st century. CA Cancer J Clin. 2000;50(4):215-36.

  27. Zitelli JA, Brown C, Hanusa BH. Mohs micrographic surgery for the treatment of primary cutaneous melanoma. J Am Acad Dermatol. 1997;37(2):236-45.

  28. Qadir MI. Medicinal and cosmetological importance of Aloe vera. Int J Nat Ther. 2009;2:21-6.

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