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Critical Reviews™ in Eukaryotic Gene Expression

Impact factor: 1.660

ISSN Print: 1045-4403
ISSN Online: 2162-6502

Critical Reviews™ in Eukaryotic Gene Expression

DOI: 10.1615/CritRevEukarGeneExpr.v22.i1.40
pages 53-59

Lysine-specific histone demethylase 1 (LSD1): A potential molecular target for tumor therapy

Yingwei Chen
Department of Gastroenterology, Shanghai Jiao Tong University, School of Medicine, Xin Hua Hospital, Shanghai, China;Shanghai Institute of Pediatric Research, Shanghai, China;Shanghai Key Laboratory of Pediatric Gastroenterology and Nutrition
Wen Jie
Shanghai Institute of Pediatric Research, Shanghai, China;Shanghai Key Laboratory of Pediatric Gastroenterology and Nutrition,China
Weihui Yan
Shanghai Institute of Pediatric Research, Shanghai, China
Kejun Zhou
Shanghai Institute of Pediatric Research, Shanghai, China;Shanghai Key Laboratory of Pediatric Gastroenterology and Nutrition,China
Yongtao Xiao
Shanghai Institute of Pediatric Research, Shanghai, China;Shanghai Key Laboratory of Pediatric Gastroenterology and Nutrition,China

ABSTRACT

Lysine-specific demethylase 1 (LSD1), the first identified histone demethylase, was belonged to the superfamily of the flavin adenine dinucleotide (FAD)-dependent amine oxidases. LSD1 specifically demethylates mono- or dimethylated dimethylated histone H3 lysine4 (H3K4) and H3 lysine 9 (H3K9) via a redox process. Recently evidences showed that LSD1 played an important role in a broad spectrum of biological processes, including cell proliferation, adipogenesis, spermatogenesis, chromosome segregation and embryonic development. Furthermore, LSD1 also could promote progress of tumor by inhibiting the tumor suppressor activity of p53. To date, as a potential drug for discovering anti-tumor drugs, the medical significance of LSD1 inhibitors have been greatly appreciated. Here, we reviewed the remarkable progress being made in understanding of LSD1, mainly on its structure, basic function and medical application in tumor therapy.