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Critical Reviews™ in Eukaryotic Gene Expression
IF: 2.156 5-Year IF: 2.255 SJR: 0.649 SNIP: 0.599 CiteScore™: 3

ISSN Print: 1045-4403
ISSN Online: 2162-6502

Critical Reviews™ in Eukaryotic Gene Expression

DOI: 10.1615/CritRevEukaryotGeneExpr.2020027084
Forthcoming Article

Strong correlation between the expression of CHEK1 and clinicopathological features of patients with multiple myeloma

Xiaoping Liu
Zhongnan hospital of Wuhan university
Qiao Huang
Zhongnan hospital of Wuhan university
Xiao-Hong Yin
Zhongnan hospital of Wuhan university
Xiang-Yu Meng
Zhongnan hospital of Wuhan university
Yue Cao
Zhongnan hospital of Wuhan university
Xin-Hui Yan
Department of Cardiology, the First Hospital of Lanzhou University
Li He
Zhongnan hospital of Wuhan university

ABSTRACT

Background: Multiple myeloma (MM) represents one of the most common malignance, and the clinical outcome of patients with MM remains poor. Objective: To screen biomarkers correlated with clinicopathological features and survival of patients with MM Methods: co-expression network was constructed to screen hub genes related with ISS staging of MM. Functional analysis and protein-protein interaction analysis of hub genes was performed. CHEK1, the most ISS staging related hub gene, was selected for further clinical validation. Results: A total number of 780 hub genes correlated with ISS staging of MM were identified. Functional enrichment of hub genes suggested that these genes were mostly enriched in several GO terms and KEGG pathways that were involved in carcinogenesis. CHEK1 was increased in MM cells from newly diagnosed patients (P = 0.0304) and relapsed MM patients (P = 0.0002) as compared to normal plasma cells. Meanwhile, CHEK1 was increased in MM patients with ISS Ⅱ disease (P = 0.0321) and ISS Ⅲ disease (P = 0.0076) than with ISS Ⅰ disease. Survival analysis indicated that MM patients in CHEK1 low expression group were associated with better clinical outcomes in terms of time to progression, event free survival, and overall survival. Conclusions: CHEK1 predicted poor clinical characteristics of MM patient, and might be regarded as a biomarker of the diagnosis of MM.