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International Journal of Physiology and Pathophysiology

ISSN Print: 2155-014X
ISSN Online: 2155-0158

International Journal of Physiology and Pathophysiology

DOI: 10.1615/IntJPhysPathophys.v7.i1.30
pages 19-29

Association of Allelic Gene Polymorphisms of Matrix Gla-Protein System with Ischemic Atherothrombotic Stroke

Viktoriia Yu. Harbuzova
Sumy State University, Sumy, Ukraine
Dmitriy A. Stroy
Bogomolets Institute of Physiology, National Academy of Sciences of Ukraine, Kyiv, Ukraine
Viktor E. Dosenko
Bogomolets Institute of Physiology, National Academy of Sciences of Ukraine, Kyiv, Ukraine
Yevheniy I. Dubovyk
Sumy State University, Sumy, Ukraine
Anastasia O. Borodenko
Sumy State University, Sumy, Ukraine
K. A. Shimko
Sumy State University, Sumy, Ukraine
Olga A. Obukhova
Sumy State University, Sumy, Ukraine
Oleksandr V. Ataman
Sumy State University, Sumy, Ukraine

ABSTRACT

We examined 10 polymorphisms of matrix Gla-protein system (gene MGP − T-138 → C (rs1800802), G-7 → A (rs1800801), Thr83 → Ala (rs4236), gene VDR − FokI (rs2228570), BsmI (rs1544410), ApaI (rs7975232), TaqI (rs731236), gene GGCX − Arg325 → Gln (rs699664), gene VKORC1 − T2255 → C (rs2359612), gene BMP-2 − Ser37 → Ala (rs2273073) in 170 patients with atherothrombotic ischemic stroke (IATS) and 124 healthy subjects (control group). It has been revealed that IATS is associated with polymorphic variants of genes MGP (G-7 → A) and VKORC1 (T2255 → C). The risk of IATS in the carriers of minor allele A/A (G-7 → A polymorphism) is 2.6 times higher than that in the carriers of the major allele (G/A + G/G), and C/C genotype (T2255 → C polymorphism) is 2.2 times higher compared to the homozygotes of a major allele. The coincidence of T/C and G/G, C/C and G/A genotypes in patients, as well as A/A genotype (G-7 → A polymorphism) with any genotype of T2255 → C polymorphism increases the risk of IATS.