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International Journal of Physiology and Pathophysiology

Published 4 issues per year

ISSN Print: 2155-014X

ISSN Online: 2155-0158

SJR: 0.116

Hemostasis Peculiarities in Hypertensive Pregnant Rats

Volume 7, Issue 1, 2016, pp. 1-8
DOI: 10.1615/IntJPhysPathophys.v7.i1.10
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ABSTRACT

The study was conducted on both non-linear white rats and spontaneously hypertensive rats (SHR). It has been revealed that the pregnant SHR often demonstrate coagulation shifts, fibrinolysis delay, hyperfibrinogenemia, and changes in two or more hemostasis chains, indicating higher thrombogenic potential in SHR group. Platelet aggregation with adenosine diphosphate and epinephrine significantly increases on the 19th − 20th day of gestation compared with pregnant nonlinear white rats. Platelet aggregation with collagen increases in non-pregnant rats with hypertension compared with pregnant animals. In the same period of gestation (19 − 20 days), the content of soluble fibrinogen and fibrin monomer complexes, and the frequency of positive ethanol test in pregnant rats with spontaneous hypertension remain higher compared with animals without this disease, which confirms the growing thrombogenic potential of blood coagulation in the SHR. In pregnant hypertensive rats, the values of euglobulin lysis were significantly higher in pregnant hypertensive rats compared to those in the group without hypertension and control rats. Weak correlation between the fibrinogen content and indicators that reflect the status of the fibrinolytic system has been found after 19 − 20 days of gestation, indicating the fibrinolysis slowing which is relatively independent on hyperfibrinogenemia in pregnant nonlinear white rats (control).

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