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International Journal of Physiology and Pathophysiology
SJR: 0.116

ISSN Print: 2155-014X
ISSN Online: 2155-0158

Archives: Volume 1, 2010 to Volume 9, 2018

International Journal of Physiology and Pathophysiology

DOI: 10.1615/IntJPhysPathophys.v5.i2.40
pages 131-140

Effect of L-Arginine on Oxygen Balance of the Liver and the Bile Secretion Function

Petro I. Yanchuk
Taras Shevchenko National University, Kyiv, Ukraine
Olena V. Bondzyk
Taras Shevchenko Kyiv National University, Kyiv, Ukraine
Yevdokiya M. Reshetnik
Kyiv National Taras Shevchenko University, Kyiv, Ukraine
Stanislav P. Veselsky
Kyiv National Taras Shevchenko University, Kyiv, Ukraine

ABSTRACT

In acute experiments on anesthetized rats, L-arginine has been shown to enhance oxygen-dependent synthetic processes in the liver, particularly those associated with mitochondrial polyenzyme systems of the bile acid biosynthesis, with simultaneous activation of hepatocyte tissue respiration. At that, the level of oxygen tension in the gland liver remains unchanged. Nitric oxide contributes only partly to implementation of these effects. Moreover, L-arginine inhibits cholepoiesis choleresis without involving NO to the reaction. Dose-dependent effect of L-arginine on the bile cholates content may indicate a different effect of the amino acid on metabolic transformation of bile acids such as hydroxylation and conjugation.