Library Subscription: Guest
Begell Digital Portal Begell Digital Library eBooks Journals References & Proceedings Research Collections
International Journal of Physiology and Pathophysiology
SJR: 0.116

ISSN Print: 2155-014X
ISSN Online: 2155-0158

Archives: Volume 1, 2010 to Volume 9, 2018

International Journal of Physiology and Pathophysiology

DOI: 10.1615/IntJPhysPathophys.v6.i3.70
pages 231-248

Alcohol-Associated Suppression of Strength Response by Musculus Gastrocnemius Caput Mediale in Rats with Critical Vascular Ischemia of Hind Limbs

Olexiy Melnychuk
Lesia Ukrainka Eastern European National University, Lutsk, Ukraine
Olexander P. Motuziuk
Lesia Ukrainka Eastern European National University, Lutsk, Ukraine
Svitlana Yu. Zay
Lesia Ukrainka Eastern European National University, Lutsk, Ukraine
Dmytro N. Nozdrenko
Taras Shevchenko National University of Kyiv, Kyiv, Ukraine
Kateryna I. Bogutska
Taras Shevchenko National University of Kyiv, Kyiv, Ukraine
Yuriy P. Sklyarov
Bogomolets National Medical University, Kyiv, Ukraine
Yuriy I. Prylutskyy
Taras Shevchenko National University of Kyiv, Kyiv, Ukraine

ABSTRACT

The change in m. gastrocnemius caput mediale strength response in alcoholic rats was studied in conditions of experimentally induced critical vascular ischemia of hind limbs. The experiment was performed on 30 male 5 months old Wistar rats weighing 145 - 150 g. Chronic alcohol intoxication of the animals was induced by intragastric delivery of 40% ethyl alcohol for 30 days. Unilateral vascular ischemia was induced by ligating a. femoralis. The mechanical activity of the muscle was registered in isometric contraction under conditions of applied stimulation. To describe the change in muscle strength response to each tetanic contraction, we calculated tetanic force, time to tetanus peak, fusion and fatigue indices. Also, for the last muscle contraction in each tetanic contraction, we calculated the time of contraction, the time of half-relaxation and speed-force index. The alcohol-associated suppression of m. gastrocnemius strength response in alcoholic rats is proved by a low initial tetanus force, which is 50% of the muscle initial force in the controls and non-alcoholic rats. The rate of decrease in the muscle tetanic force during the experiment with alcoholic rats proved to be greater than that in non-alcoholic rats. This fact together with the low values of isometric force developed by the muscle evidences that muscle atrophy in the animals is caused by alcohol. However, no pronounced differences have been found for the time of attaining tetanic force peak and fusion index for alcoholic rats in comparison with non-alcoholic animals. The analysis of time course of the last muscular contraction in tetanus has not revealed any profound change in duration of intervals between contractility in the tetanus. However, we have found reliable changes in the direction of muscle force development: in alcoholic and non-alcoholic rats the muscle develops force at an acute angle in comparison with the controls, which indicates ischemia-associated destabilization of myofibrils. The obtained results show the gathering evidence of the synergy of ethyl alcohol myotoxic effects and destructive influence of vascular ischemia by reducing contractility of m. gastrocnemius in alcoholic rats, which results in intensified ischemia-associated motor dysfunction.


Articles with similar content:

Static Stretch Training in Conditions of Simulated Microgravity Maintains Contractile Properties of Muscles?
International Journal of Physiology and Pathophysiology, Vol.2, 2011, issue 3
Yuri Koryak
Dynamics of Regeneration of Striated Muscles in Rats with Posttraumatic Reflex Contractures
International Journal of Physiology and Pathophysiology, Vol.9, 2018, issue 3
Victoria V. Pankevych, Svetlana V. Ushtan, Ulyana D. Matolych
Physiological Endurance of Skeletal Muscle Increases under C60 Fullerene Application before Physical Load
International Journal of Physiology and Pathophysiology, Vol.9, 2018, issue 4
Uwe Ritter, Larisa Bezuh, Yuriy I. Prylutskyy, Tetyana Yu. Matvienko, Sofia Paradizova, Peter Scharff, Kateryna I. Bogutska, Iryna V. Mishchenko, Danylo Zavodovskiy
Effect of Geomagnetic Storms on the Erythrocyte Sedimentation Rate in Ischemic Patients
Critical Reviews™ in Biomedical Engineering, Vol.29, 2001, issue 1
S. E. Kondakov, Yu. I. Gurfinkel, E. V. Buravlyova, V. L Voeikov
ADHD and Motor Control: A Review of the Motor Control Deficiencies Associated With Attention Deficit/Hyperactivity Disorder and Current Treatment Options
Critical Reviews™ in Physical and Rehabilitation Medicine, Vol.25, 2013, issue 3-4
Nancy McNevin, Marc Michael Demers, Nadia R. Azar