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International Journal of Physiology and Pathophysiology
SJR: 0.106

ISSN Print: 2155-014X
ISSN Online: 2155-0158

Archives: Volume 1, 2010 to Volume 9, 2018

International Journal of Physiology and Pathophysiology

DOI: 10.1615/IntJPhysPathophys.v4.i2.40
pages 113-121

Features of Histostructural Changes in Rat Cerebral Cortex in Hemorrhagic Stroke Modeling

Sergiy I. Savosko
Bogomolets Institute of Physiology, National Academy of Sciences of Ukraine, Kyiv, Ukraine
Juriy B. Chaikovsky
Bogomolets National Medical University, Kyiv, Ukraine
Nelly Kh. Pogorela
Bogomoletz Institute of Physiology of National Academy of Science of Ukraine, Kyiv
Alexandr N. Makarenko
The Institute of Higher Nervous Activity and Neurophysiology, Russian Academy of Sciences, Moscow, Russia

ABSTRACT

The features of pathological changes in modeling the primary and recurrent acute hemorrhagic stroke were studied in rats. The differences in the pharmacological activity of the medicinal drugs in acute stroke have been revealed. The drugs increased survival of the neurons in both hemispheres of rat cerebrum at right-side primary and recurrent hemorrhagic stroke. In recurrent stroke, the number of degenerative neurons has been shown to be (25.5 ± 0.8) cells/mm2, after administration of cerebrolysin, cortexin and cerebral, the number of degenerative neurons is (17.6 ± 1.7) cells/mm2, (18.0 ± 0.9) cells/mm2, and 10.7 ± 0.4) cells/mm2, respectively, while in control animals, it do not exceed 2% and averages (1.5 ± 0.1) cells/mm2. An analysis of morphological and statistical data has shown that cortexin and cerebral are the most effective remedies under the primary and recurrent hemorrhagic stroke, while the latter has more pronounced effect.


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