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International Journal of Physiology and Pathophysiology
SJR: 0.116

ISSN Print: 2155-014X
ISSN Online: 2155-0158

Archives: Volume 1, 2010 to Volume 9, 2018

International Journal of Physiology and Pathophysiology

DOI: 10.1615/IntJPhysPathophys.v4.i2.30
pages 103-112

Matrix Gla-Protein Gene Polymorphism in Patients with Ischemic Atherothrombotic Stroke

Victoria Yu. Garbuzova
Sumy State University, Ukraine
Olga I. Matlay
Sumy State University, Sumy, Ukraine
Juriy A. Ataman
Sumy State University, Sumy, Ukraine
Yevheniy I. Dubovyk
Sumy State University, Sumy, Ukraine
Anastasia O. Borodenko
Sumy State University, Sumy, Ukraine
Olga A. Obukhova
Sumy State University, Sumy, Ukraine
Oleksandr V. Ataman
Sumy State University, Sumy, Ukraine

ABSTRACT

Matrix Gla-protein (MGP) gene allelic polymorphism was determined in 170 patients with ischemic atherothrombotic stroke (IATS) and in 124 healthy subjects (control group). It has been shown that in patients with IATS the ratio of main homozygotes, heterozygotes and minor homozygotes is 61.2, 31.2, and 7.6%, respectively, when analyzing T−138 → C (rs1800802) promoter polymorphism (in the control group, it is 59.7, 35.6, and 4.8%, P = 0.521 by χ2-test); it is 35.9, 48.8, and 15.3% for G−7 → A (rs1800801) promotor polymorphism (in the controlgroup, it is 43.5, 50.0, and 6.5%, P = 0.051); and it is 39.4, 48.8, and 11.8% for Thr83 → Ala (rs4236) polymorphism of the 4th exon (in control group, it is 34.7, 53.2, and 12.1%, P = 0.701). Significant difference in the frequency of G−7 → A polymorphism between the patients with IATS and the control group were revealed only for women (P = 0.022). The results obtained suggest that the A/A-variations of MGP gene promotor (G−7 → A polymorphism) is associated with an increased risk of IATS in females in Ukrainian population.