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International Journal of Physiology and Pathophysiology
SJR: 0.116

ISSN Print: 2155-014X
ISSN Online: 2155-0158

Archives: Volume 1, 2010 to Volume 9, 2018

International Journal of Physiology and Pathophysiology

DOI: 10.1615/IntJPhysPathophys.v4.i2.80
pages 157-170

Food-Procuring Stereotype Movements is Accompanied by Changes of c-fos Gene Expression in the Amygdala and Modulation of Heart Rate in Rats

Olexandr V. Dovgan'
Pirogov National Medical University, Vinnitsa, Ukraine
Oleh V. Vlasenko
Pirogov National Medical University, Vinnitsa, Ukraine
Igor L. Rokunets
Pirogov National Medical University, Vinnitsa, Ukraine
Tetyana V. Buzyka
Mechnikov National University, Odessa, Ukraine
Volodymyr A. Maisky
Bogomoletz Institute of Physiology of the NAS of Ukraine, Kyiv, Ukraine
Olexandr I. Pilyavskii
Bogomoletz Institute of Physiology of the NAS of Ukraine, Kyiv, Ukraine
Andriy V. Maznychenko
Bogomoletz Institute of Physiology of the NAS of Ukraine, Kyiv, Ukraine

ABSTRACT

The distribution of Fos-immunoreactive (Fos-ir-) and NADPH-diaphorase reactive (NADPH-dr-) neurons in different amygdaloid subnuclei and insular cortex (on the levels - 2.12 − -3.14 mm from bregma), and associated changes in the heart rate (HR) in intact, fooddeprivated and executed food-procuring movements of rats were studied. In comparison with other groups of animals, the mean number of Fos-ir neurons in the central nucleus of amygdala (Ce) and the insular cortex (GI/DI) at all studied levels is significantly greater in rats executed food-procuring movements. The main focus of the Fos-ir neurons has been found in the lateral part of the Ce (58.5 ± 1.9 cells in a 40-μm-thick section) at the level of -2.56 mm. The mean number of activated neurons was significantly greater also in the medial and capsular parts of the Ce. In GI/DI, the mean number of Fos-ir neurons was 165.5 ± 3.2 cells in a section. However, the mean number and density of NADPH-dr neurons was not significantly different in the brain structures of all studied animals. The double staining neurons (Fos-ir + NADPH-dr) were registered in the medial, basolateral, anterior cortical amygdaloid nuclei and the substantia innominata (SI) in rats after realization food-procuring movements. It was found that realization of food-procuring movements by the forelimb during repeated training sessions was accompanied with the gradual decline of mean values of the HR (from 5% to 12% of control level) with subsequent renewal of them to the initial values (tonic component). The analysis of the HR changes during realization of separate purposeful motion has shown the transient period of the HR suppression (500 ms), which coincided with the terminal phase of grasping of food pellet (phasic component). We suggest that revealed focuses of Fos-immunoreactivity in the lateral and medial parts of the Ce and also GI/DI, and SI testified that these brain structures are involved in generation of the goal-directed movements. Direct projections of these subnuclei (and hypothalamus) to the cardiovascular centers of the medulla determine the associated regulation of the cardiovascular system function in the period of realization of the goal-directed motions in animals.


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