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International Journal of Physiology and Pathophysiology
SJR: 0.116

ISSN Print: 2155-014X
ISSN Online: 2155-0158

Archives: Volume 1, 2010 to Volume 9, 2018

International Journal of Physiology and Pathophysiology

DOI: 10.1615/IntJPhysPathophys.v9.i4.80
pages 349-361

Physiological Endurance of Skeletal Muscle Increases under C60 Fullerene Application before Physical Load

Tetyana Yu. Matvienko
Taras Shevchenko National University of Kyiv, Kyiv, Ukraine
Danylo Zavodovskiy
Bogomolets Institute of Physiology, NAS of Ukraine, Kyiv, Ukraine
Iryna V. Mishchenko
Lesya Ukrainka Eastern European National University, Lutsk, Ukraine
Kateryna I. Bogutska
Taras Shevchenko National University of Kyiv, Kyiv, Ukraine
Yuriy I. Prylutskyy
Taras Shevchenko National University of Kyiv, Kyiv, Ukraine
Sofia Paradizova
The State Institution "The Territorial Medical Association of the Ministry of Internal Affairs of Ukraine in Kyiv", Kyiv, Ukraine
Larisa Bezuh
The State Institution "The Territorial Medical Association of the Ministry of Internal Affairs of Ukraine in Kyiv", Kyiv, Ukraine
Uwe Ritter
Institute of Chemistry and Biotechnology, Technical University of Ilmenau, Ilmenau, Germany
Peter Scharff
Institute of Chemistry and Biotechnology, Technical University of Ilmenau, Ilmenau, Germany

ABSTRACT

Ability of pristine C60 fullerene aqueous colloid solution (C60FAS) to increase the skeletal muscle fatigue threshold and significantly improve the muscle response to monotonously repeated long-time stimulation was demonstrated in experiments on the soleus muscle of male Wistar rats. The significant positive biomechanical changes in the development of muscle fatigue, which were caused by C60FAS intramuscular administration, strongly correlate with changes in blood biochemical markers of muscle fatigue, such as creatine phosphokinase, lactate dehydrogenase, and creatinine. As a result, a therapeutic usage of C60FAS in an optimal dose of 1 mg/kg contributes to the effective recovery of investigated contraction parameters of skeletal muscles almost to baseline. This clearly shows a promising biomedical C60FAS application for the muscle fatigue correction and improvement of functional capacity of skeletal muscles.


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