Library Subscription: Guest
Begell Digital Portal Begell Digital Library eBooks Journals References & Proceedings Research Collections
International Journal of Physiology and Pathophysiology

ISSN Print: 2155-014X
ISSN Online: 2155-0158

International Journal of Physiology and Pathophysiology

DOI: 10.1615/IntJPhysPathophys.v4.i4.70
pages 335-343

Effect of Corvitin on Secretory Processes and Blood Flow in the Rat Gastric Mucosa

Tetyana V. Vovkun
Kyiv Taras Shevchenko National University, Kyiv, Ukraine
Petro I. Yanchuk
Peter Bogach Institute of Physiology Biology Department, National Taras Shevchenko University, Kiev, Ukraine
Lydia Y. Shtanova
Kyiv Taras Shevchenko National University, Kyiv, Ukraine
Stanislav P. Veselsky
Taras Shevchenko National University, Bogach Institute of Physiology, Kyiv, Ukraine
Vasyl A. Baranowskyy
Kyiv Taras Shevchenko National University, Kyiv, Ukraine

ABSTRACT

We studied the volume and biochemical components of gastric secretion in pylorus-ligated rats and the blood flow in the gastric mucosa of exposed to Corvitin rats in doses of 2.5 and 5 mg / kg, intragastrically. Biochemical analysis of gastric secretion was based on determining the flow rate of hydrochloric acid, concentrations of protein, hexosamines (per glucosamine) and cysteine. In control rats, hexosamines, gastric mucus indicators, and free amino acid cysteine, a powerful antioxidant, have been detected. Corvitin evoked an increase in concentration of these compounds in the gastric juice. However, it did not affect the gastric secretion parameters, such as pH, volume of gastric secretion, hydrochloric acid debit, the concentration of protein. It has been also shown that this drug increases the blood flow in the gastric mucosa in a dose-dependent manner. The results obtained give reason to believe that Corvitin can be considered as a tool to increase gastric mucosa protection mechanisms without affecting the secretion of hydrochloric acid and protein.