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International Journal of Physiology and Pathophysiology
SJR: 0.116

ISSN Print: 2155-014X
ISSN Online: 2155-0158

Archives: Volume 1, 2010 to Volume 9, 2018

International Journal of Physiology and Pathophysiology

DOI: 10.1615/IntJPhysPathophys.v4.i4.10
pages 273-283

Efficiency of ω-3 Polyunsaturated Fatty Acids at Physical Exercise

Larysa M. Gunina
Scientific Institute of the National University of Physical Education and Sport of Ukraine, Kyiv, Ukraine
Ivan S. Chekman
National Institute of Physical Education and Sport, Kyiv, Ukraine
Tetyana Yu. Nebesna
National Institute of Physical Education and Sport, Kyiv, Ukraine
Nadia O. Gorchakova
National Institute of Physical Education and Sport, Kyiv, Ukraine

ABSTRACT

Based on the results of quantum-chemical studies with the analysis of the atomic structure of the molecule, it has been shown that ω-3 polyunsaturated fatty acids have distinct antioxidant and membranoprotective properties, similar to tocopherol, a bioantioxidant carotenoid. Epadol, the drug made on the base of ω-3 polyunsaturated fatty acids, has been shown to inhibit simultaneously lipid peroxidation (which is manifested as a decrease in malonic dialdehyde content) and to promote an improvement of the antioxidant defense, represented by an increase in the concentration of reduced glutathione in erythrocyte membranes. The use of this remedy for athletes results in a decrease in pro-oxidative-anti-oxidative ratio from 2.44 to 1.34, indicating the antioxidant properties of Epadol. However, the erythrocyte sorption capacity, which characterizes the functional properties of their membranes, when exposed to Epadol decreases from (35.04 ± 2.23)% to (25.3 ± 1.07)%, which counteracts to aggregation of erythrocytes. An expediency of using Epadol, the domestic medical remedy, in practice of athletes training to improve structural and functional status of the cell membranes and prevent uncontrolled apoptosis has being discussed.