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International Journal of Physiology and Pathophysiology
SJR: 0.106

ISSN Print: 2155-014X
ISSN Online: 2155-0158

Archives: Volume 1, 2010 to Volume 9, 2018

International Journal of Physiology and Pathophysiology

DOI: 10.1615/IntJPhysPathophys.v3.i2.70
pages 175-184

Effects of Cytokine-Like Polypeptide EMAP II and Flutamide on Testosterone-Stimulated Prostate of Castrated Rats

Alexander G. Reznikov
V.P.Komissarenko Institute of Endocrinology and Metabolism of National Academy of Medical Sciences of Ukraine, Kyiv, Ukraine
L. V. Chaikovskaya
VP.Komissarenko Institute of Endocrinology and Metabolism of National Academy of Medical Sciences of Ukraine, Kyiv, Ukraine
L. I. Polyakova
VP.Komissarenko Institute of Endocrinology and Metabolism of National Academy of Medical Sciences of Ukraine, Kyiv, Ukraine
Olga V. Sachynska
Komissarenko Institute of Endocrinology and Metabolism, Kyiv, Ukraine; Zaporozhye State Medical Academy for Postgraduate Education, Zaporozhye, Ukraine

ABSTRACT

The effects of separate and combined administration of cytokine-like polypeptide EMAP II and flutamide, a non-steroid antiandrogen, on morphologyy and function of the accessory sexual glands in castrated immature male rats stimulated with testosterone propionate were studied. Anti-androgenic, pro-apoptotic, and pro-coagulating effects of EMAP II have been revealed in the ventral prostate. Combined use of the drugs resulted in enhanced anti-prostatic effects capable of inhibiting the processes of proliferation and apoptosis, as well as DNA, RNA and protein contents. Combined use of EMAP II and flutamide may be useful in developing new therapeutic modalities in prostate cancer.


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