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International Journal of Physiology and Pathophysiology
SJR: 0.106

ISSN Print: 2155-014X
ISSN Online: 2155-0158

Archives: Volume 1, 2010 to Volume 9, 2018

International Journal of Physiology and Pathophysiology

DOI: 10.1615/IntJPhysPathophys.v9.i3.40
pages 221-228

Endothelial Monocyte-Activating Polypeptide-II Improves Diastolic Heart Function and Vascular Relaxation in Type-I Diabetes Mellitus

Nataliya A. Dorofeyeva
Bogomolets Institute of Physiology of National Academy of Sciences of Ukraine, Kyiv, Ukraine
Georgiy G. Vorobyov
Bogomolets Institute of Physiology, National Academy of Sciences of Ukraine, Kyiv, Ukraine
I. Y. Cherepaxa
Institute of Molecular Biology and Genetics, National Academy of Sciences of Ukraine, Kyiv, Ukraine
Alexander I. Kornelyuk
Institute of Molecular Biology and Genetics, National Academy of Sciences of Ukraine, Kyiv, Ukraine
Vadim F. Sagach
Bogomolets Institute of Physiology, National Academy of Sciences of Ukraine, Kyiv, Ukraine

ABSTRACT

To investigate the effects of endothelial monocyte-activating poly-peptide-II (EMAP II) on cardiac function and endothelium-dependent relaxation of aortic smooth muscles in streptozotocin-induced diabetes mellitus, experiments were conducted on 6-months-old male Wistar rats. In in vivo experiments, it has been shown that EMAP II improves diastolic function of the heart in streptozotocin-induced diabetic rats, which is evidenced by decreasing left ventricular end-diastolic pressure and end-diastolic myocardial stiffness by 13.8% and 26.3% (P < 0.05), respectively, compared to 25.4% (P < 0.05) and 25.5% (P < 0.05), respectively, in diabetic rats. EMAP II also decreases end-systolic pressure and arterial stiffness. In in vitro experiments on isolated aortic rings, it has been revealed that EMAP II improves endothelium-dependent relaxation of smooth muscles in strep-tozotocin-induced diabetic rats. An inhibition of NO-synthase (NOS) activity with L-NAME abolished EMAP Il-mediated vasodilatation in the endothelium-intact aortic rings, which indicates NOS-dependent mechanism of EMAP II action. Thus, EMAP II has a protective effect on the heart and vessels of rats with streptozotocin-induced diabetes. It improves diastolic heart function and restores vasorelaxation in diabetes mellitus.


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