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International Journal of Physiology and Pathophysiology
SJR: 0.106

ISSN Print: 2155-014X
ISSN Online: 2155-0158

Archives: Volume 1, 2010 to Volume 9, 2018

International Journal of Physiology and Pathophysiology

DOI: 10.1615/IntJPhysPathophys.v6.i4.40
pages 299-312

Modulation of Rat Myometrium Contractile Activity by Peptidocycan of Staphfylococcus Aureus Cell Wall

Lilit S. Nasibyan
Bogomoletz Institute of Physiology of the National Academy of Sciences of Ukraine, Kyiv, Ukraine
Igor B. Philyppov
Bogomoletz Institute of Physiology of the National Academy of Sciences of Ukraine, Kyiv, Ukraine

ABSTRACT

An impact of Peptidoclycan of Staphylococcus aureus cell wall on the contractile activity of the myometrium from estrogen-treated and pseudopragnant rats was studied. The results of experiments have shown that the rat myometrium sensitivity to peptidoglycan depends on the hormonal background. Peptidoglycan modifies the myometrium contractile activity of both estrogen-treated and pseudopragnant rats. In estrogen-treated rat myometrium, peptidoglycan reduces frequency and duration of the contractions (it elongates the uterine cycle), while in the pseudopregnant rat myometrium, it increases the amplitude, duration, and the frequency (reducing the uterine cycle). We have revealed that peptidoglycan has stronger uterotonic effect compared to that of prostaglandin F2α (10 μmol/l). Based on this fact, we have concluded that peptidoglycan-induced changes in the myometral contractile activity may have negative impact on fertility and the course of pregnancy.


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