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International Journal of Physiology and Pathophysiology

Published 4 issues per year

ISSN Print: 2155-014X

ISSN Online: 2155-0158

SJR: 0.116

Thymic Hormones, Antioxidant Enzymes and Neurogenesis in Bulbus Olfactorius of Rats with Hemiparkinsonism: Effect of Melatonin

Volume 7, Issue 4, 2016, pp. 285-298
DOI: 10.1615/IntJPhysPathophys.v7.i4.10
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ABSTRACT

In rats receiving only neurotoxin 6-hydroxydopamine or its combination with melatonin, we investigated the relationship between disorders of the brain antioxidant enzymes and the endocrine function of the thymus as possible pathogenetic links of parkinsonism with changes in the number of neural stem cells (NSC) in the bulbus olfactorius. It has been found that in rats with motor asymmetry in apomorphine test that meets significant damage to dopaminergic neurons in substantia nigra, the activities of superoxide dismutase, catalase and glutathione reductase decrease in the striatum 1.3 - 1.4 times, and blood thymulin content decreases 8 times) compared to pseudo-operated animals (P < 0.05). On the contrary, examined indices were not changed in rats without motor asymmetry and correspondingly partly damaged neurons. The portion of nestin+-cells in the bulbus olfactorius of rats without motor asymmetry increased from 91.2 to 99.3% and remained unchanged after the course of melatonin (10 mg / kg for 18 days). Melatonin administration resulted in the decrease in the number of nestin+ -cells along with significant elevation of the decreased antioxidant enzymes activity and blood thymulin content in rats with circulatory movements. The possibilities of enhanced NSC differentiation in the bulbus olfactorius into neuronal direction have been discussed. The prospects of the use of melatonin as a neuroprotective method in the treatment of Parkinson's disease is substantiated.

CITED BY
  1. Labunets I. F., Chaikovsky Yu. B., Savosko S. I., Butenko G. M., Sagach V. F., Kop’yak B. S., Effects of Melatonin on the Behavioral Indices and Structural Characteristics of Cerebral and Spinal Neurons of Rats with Experimental Hemiparkinsonism, Neurophysiology, 50, 1, 2018. Crossref

  2. Labunets I. F., Rodnichenko A. E., Melatonin Effects in Young and Aging Mice with the Toxic Cuprizone-Induced Demyelination, Advances in Gerontology, 10, 1, 2020. Crossref

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