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International Journal of Physiology and Pathophysiology
SJR: 0.116

ISSN Print: 2155-014X
ISSN Online: 2155-0158

Archives: Volume 1, 2010 to Volume 9, 2018

International Journal of Physiology and Pathophysiology

DOI: 10.1615/IntJPhysPathophys.v7.i4.40
pages 321-329

Effect of Sodium Hydrosulfide (NaHS) on Oxidative/Nitrosative Stress and Endothelium-Dependent Relaxation in Old Rats

Konstantin O. Drachuk
Bogomolets Institute of Physiology, National Academy of Sciences of Ukraine, Kyiv, Ukraine
Anatoliy V. Kotsuruba
Bogomolets Institute of Physiology, National Academy of Sciences of Ukraine, Kyiv, Ukraine
Vadim F. Sagach
Bogomolets Institute of Physiology, National Academy of Sciences of Ukraine, Kyiv, Ukraine

ABSTRACT

The effects of hydrogen sulfide donor, sodium hydrosulfide (NaHS) on indicators of oxidative and nitrosative stress, coupling of constitutive NO-synthase (cNOS) and endothelium-dependent relaxation of smooth muslles (SM) were studied in old rats. In the aorta of old rats, a combined oxidative and nitrosative stress developed resulting in cNOS uncoupling and decreased constitutive synthesis of NO. The biochemical changes correlated with lowering of the endothelium-dependent relaxation of aortic smooth muscles (7.5 ± 1.4%, compared with 64.9 ± 3.5% in control group of adult animals). It has been shown that NaHS significantly inhibited oxidative /nitrisative stress, restoring cNOS coupling and increasing constitutive synthesis of NO. The latter promotes an improvement of endothelium-dependent vasorelaxation by increasing (by 6.5 times) Ach-induced relaxation of aortic smooth muscles.