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International Journal of Physiology and Pathophysiology

Published 4 issues per year

ISSN Print: 2155-014X

ISSN Online: 2155-0158

SJR: 0.116

Effect of Sodium Hydrosulfide (NaHS) on Oxidative/Nitrosative Stress and Endothelium-Dependent Relaxation in Old Rats

Volume 7, Issue 4, 2016, pp. 321-329
DOI: 10.1615/IntJPhysPathophys.v7.i4.40
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ABSTRACT

The effects of hydrogen sulfide donor, sodium hydrosulfide (NaHS) on indicators of oxidative and nitrosative stress, coupling of constitutive NO-synthase (cNOS) and endothelium-dependent relaxation of smooth muslles (SM) were studied in old rats. In the aorta of old rats, a combined oxidative and nitrosative stress developed resulting in cNOS uncoupling and decreased constitutive synthesis of NO. The biochemical changes correlated with lowering of the endothelium-dependent relaxation of aortic smooth muscles (7.5 ± 1.4%, compared with 64.9 ± 3.5% in control group of adult animals). It has been shown that NaHS significantly inhibited oxidative /nitrisative stress, restoring cNOS coupling and increasing constitutive synthesis of NO. The latter promotes an improvement of endothelium-dependent vasorelaxation by increasing (by 6.5 times) Ach-induced relaxation of aortic smooth muscles.

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