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International Journal of Medicinal Mushrooms
IF: 1.423 5-Year IF: 1.525 SJR: 0.431 SNIP: 0.661 CiteScore™: 1.38

ISSN Print: 1521-9437
ISSN Online: 1940-4344

International Journal of Medicinal Mushrooms

DOI: 10.1615/IntJMedMushr.v15.i6.40
pages 555-568

Anticonvulsant and Neuroprotective Effects of Oligosaccharides from Lingzhi or Reishi Medicinal Mushroom, Ganoderma lucidum (Higher Basidiomycetes)

Alma Aguirre-Moreno
Facultad de Farmacia, Universidad Autonoma del Estado de Morelos, Avenida Universidad 1001, Col. Chamilpa 62209 Cuernavaca, Morelos, México
Victoria Campos-Pena
Laboratorio de Enfermedades Neurodegenerativas, Instituto Nacional de Neurologia, MVS, SSA. Insurgentes Sur 3877, Col. La Fama 14269 Distrito Federal, México
Federico del Rio-Portilla
Instituto de Quimica, Universidad Nacional Autonoma de México, Circuito Exterior, Ciudad Universitaria, Coyoacan 04510, Distrito Federal, México
Maribel Herrera-Ruiz
Centro de Investigacion Biomédica del Sur, Instituto Mexicano del Seguro Social, Argentina 1 Col. Centro, 62790 Xochitepec, Morelos, México
Ismael Leon-Rivera
Centro de Investigaciones Quimicas, Universidad Autonoma del Estado de Morelos, Avenida Universidad 1001, Col. Chamilpa 62209 Cuernavaca, Morelos, México. www.ciq.uaem.mx/
Elizur Montiel-Arcos
Centro de Investigaciones Biologicas, Universidad Autonoma del Estado de Morelos, Avenida Universidad 1001, Col. Chamilpa 62209 Cuernavaca, Morelos, México
Veronica Rodriguez
Facultad de Farmacia, Universidad Autonoma del Estado de Morelos, Avenida Universidad 1001, Col. Chamilpa 62209 Cuernavaca, Morelos, México
Isaac Tello
Centro de Investigaciones Biologicas, Universidad Autonoma del Estado de Morelos, Avenida Universidad 1001, Col. Chamilpa 62209 Cuernavaca, Morelos, México
Juana Villeda-Hernandez
Laboratorio Experimental de Neuropatologia, Instituto Nacional de Neurologia, MVS, SSA. Insurgentes Sur 3877, Col. La Fama 14269 Distrito Federal, México

ABSTRACT

An oligosaccharide fraction isolated from the mycelium of the Lingzhi or Reishi medicinal mushroom Ganoderma lucidum (GLOS) was separated by size-exclusion chromatography. The chemical structure of GLOS consists of a disaccharide repeating unit [-4-β-1-Galf(1-6)-O-(β-Glcp)−1-]n (n=3,4). In addition, this study was undertaken to determine the possible anticonvulsant and neuroprotective effects of GLOS (10−80 mg/kg) on kainic acid (KA)-induced seizures. The behavioral alterations and histopathology of hippocampal neurons were studied. Our results show that GLOS inhibited convulsions in rats from KA-induced seizures, reduced the degeneration pattern in the CA3 region of rats, decreased astrocytic reactivity, and reduced the expression of IL-1β and TNF-α induced by KA. These results indicate a potential anticonvulsant and neuroprotective effects of GLOS.