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International Journal of Medicinal Mushrooms

Published 12 issues per year

ISSN Print: 1521-9437

ISSN Online: 1940-4344

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A Phase I/II Study of Ling Zhi Mushroom Ganoderma lucidum (W.Curt.:Fr.)Lloyd (Aphyllophoromycetideae) Extract in Patients with Type II Diabetes Mellitus

Volume 6, Issue 1, 2004, 8 pages
DOI: 10.1615/IntJMedMushr.v6.i1.30
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ABSTRACT

Animal studies have demonstrated that the polysaccharide fractions of Ganoderma lucidum (Ling Zhi, reishi mushroom) have potential hypoglycemic and hypolipidemic activities. This clinical study aimed to evaluate the efficacy and safety of Ganopoly (polysaccharide fractions extracted from G. lucidum by patented technique) in 71 patients with confirmed type II diabetes mellitus (DM). Eligibility criteria included type II DM of >3 months’ duration for which patients were not receiving insulin; age >18 years; normal vital signs for age and disease state; normal electrocardiogram (ECG); and fasting plasma glucose (FPG) level of 8.9.16.7 mmol/L in sulfonylurea-naive patients or an FPG <10 mmol/L before washout in sulfonylurea-treated patients. Patients were randomly grouped to be given either Ganopoly or placebo orally at 1800 mg three times daily for 12 weeks. Patients underwent 4 weeks of dose adjustment followed by 8 weeks of dose maintenance. Fasting and stimulated glycosylated hemoglobin (HbA1c), plasma glucose, insulin, and C-peptide were monitered at predetermined intervals. Adverse events and hypoglycemic episodes were recorded. The treatment of Ganopoly significantly decreased the mean HbA1c from 8.4 at baseline to 7.6% at 12 weeks. Significant changes in mean FPG and PPG levels at the last visit paralleled the changes in mean HbA1c levels. At baseline, the mean FPG and PPG values in patients treated with Ganopoly were 12.0 and 13.6 mmol/L, respectively. At week 12, mean PPG values had decreased to 11.8 mmol/L. However, these parameters did not change or slightly increased in patients receiving placebo. The between-group difference in PPG levels at week 12 was significant (p < 0.05). Changes in fasting insulin, 2-hour post-prandial insulin, fasting C-peptide, and 2-hour post-prandial C-peptide were consistent, with the between-group differences in these end points being significant at the last visit. Overall, Ganopoly was well tolerated. This study demonstrated that Ganopoly was efficacious and safe in lowering blood glucose concentrations.

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  3. Chu Qing-Ping, Wang Li-En, Cui Xiang-Yu, Fu Hong-Zheng, Lin Zhi-Bin, Lin Shu-Qian, Zhang Yong-He, Extract of Ganoderma lucidum potentiates pentobarbital-induced sleep via a GABAergic mechanism, Pharmacology Biochemistry and Behavior, 86, 4, 2007. Crossref

  4. Tang Wenbo, Gao Yihuai, Chen Guoliang, Gao He, Dai Xihu, Ye Jinxian, Chan Eli, Huang Min, Zhou Shufeng, A Randomized, Double-Blind and Placebo-Controlled Study of aGanoderma lucidumPolysaccharide Extract in Neurasthenia, Journal of Medicinal Food, 8, 1, 2005. Crossref

  5. Yuen John, Buswell John, Benzie Iris, Ganoderma lucidum (Lingzhi or Reishi), in Herbal Medicine, 20115386, 2011. Crossref

  6. Lim Chee Wei, Chan Sheot Harn, Visconti Angelo, Feed-forward neural network assisted by discriminant analysis for the spectroscopic discriminantion of cracked spores Ganoderma lucidum: A prospective biotechnology production tool, AMB Express, 1, 1, 2011. Crossref

  7. Meng Guoliang, Zhu Hongyan, Yang Shengju, Wu Feng, Zheng Huihua, Chen E, Xu Jiliang, Attenuating effects of Ganoderma lucidum polysaccharides on myocardial collagen cross-linking relates to advanced glycation end product and antioxidant enzymes in high-fat-diet and streptozotocin-induced diabetic rats, Carbohydrate Polymers, 84, 1, 2011. Crossref

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  26. Sangeetha B., Krishnamoorthy A.S., Renukadevi P., Malathi V.G., Jeya Sundara Sharmila D., Amirtham D., Antiviral activity of basidiomycetous fungi against Groundnut bud necrosis virus in tomato, Pesticide Biochemistry and Physiology, 166, 2020. Crossref

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  29. Sharifi-Rad Javad, Butnariu Monica, Ezzat Shahira M., Adetunji Charles Oluwaseun, Imran Muhammad, Sobhani Seyyed Reza, Tufail Tabussam, Hosseinabadi Tahereh, Ramírez-Alarcón Karina, Martorell Miquel, Maroyi Alfred, Martins Natália, Mushrooms-Rich Preparations on Wound Healing: From Nutritional to Medicinal Attributes, Frontiers in Pharmacology, 11, 2020. Crossref

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