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International Journal of Medicinal Mushrooms

Impact factor: 1.211

ISSN Print: 1521-9437
ISSN Online: 1940-4344

International Journal of Medicinal Mushrooms

DOI: 10.1615/IntJMedMushrooms.v18.i5.60
pages 425-431

Black Hoof Medicinal Mushroom Phellinus linteus (Agaricomycetes) Extracts Protect Against Radiation-Induced Hematopoietic Abnormality in Mice

Shu-Ming Huang
Department of Food Science and Biotechnology, National Chung Hsing University, Taichung, Taiwan, R.O.C.; Department of Nutrition, Nantou Hospital, Ministry of Health and Welfare, Nantou City, Taiwan, R.O.C.
Jen-Yin Chen
Department of Anesthesiology, Chi Mei Medical Center, Tainan, Taiwan, R.O.C.
Chin-Chu Chen
Biotechnology Center, Grape King Bio Ltd., Chung Li, Taiwan, ROC
Chih-Chung Su
Department of Oncology, Jan-Ai Hospital-DaLi, Taichung, Taiwan, R.O.C.
Miao-Lin Hu
Department of Food Science and Biotechnology, National Chung Hsing University, Taichung, Taiwan, R.O.C.; Agricultural Biotechnology Center, National Chung Hsing University, Taichung, Taiwan, R.O.C.

ABSTRACT

We investigated the effects of Phellinus linteus extracts (PLEs) against radiation damage in mice. First, BALB/c mice were irradiated once with γ-rays at 4, 5, 6, or 8 Gy and allowed to recover for 20 days. Results reveal that 8-Gy radiation caused death in 100% of mice on day 13, and 6-Gy radiation caused death in 86.7% of mice (13/15) at the end of the experiment, whereas 4- and 5-Gy radiation did not result in any death. We then used 5-Gy γ-ray radiation to examine the protective effects of PLEs. Mice were orally administered a PLE (500, 1000, and 1500 mg/kg) daily for 2 weeks before radiation and for 6 weeks after radiation. γ-Ray radiation significantly decreased body weight starting from week 2 after radiation. Supplementation with a median and high dose of PLE significantly restored body weights starting at weeks 5 and 3, respectively. The radiation-protective agent WR2721 (200 mg/kg intraperitoneally) restored body weights starting at week 4. White blood cells, platelets, red blood cells, and hemoglobin were significantly decreased by radiation, and PLEs (primarily at high doses) and WR2721 significantly prevented hematologic abnormality. These results suggest that PLE has potential as a radioprotective agent.