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International Journal of Medicinal Mushrooms

Published 12 issues per year

ISSN Print: 1521-9437

ISSN Online: 1940-4344

The Impact Factor measures the average number of citations received in a particular year by papers published in the journal during the two preceding years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) IF: 1.2 To calculate the five year Impact Factor, citations are counted in 2017 to the previous five years and divided by the source items published in the previous five years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) 5-Year IF: 1.4 The Immediacy Index is the average number of times an article is cited in the year it is published. The journal Immediacy Index indicates how quickly articles in a journal are cited. Immediacy Index: 0.3 The Eigenfactor score, developed by Jevin West and Carl Bergstrom at the University of Washington, is a rating of the total importance of a scientific journal. Journals are rated according to the number of incoming citations, with citations from highly ranked journals weighted to make a larger contribution to the eigenfactor than those from poorly ranked journals. Eigenfactor: 0.00066 The Journal Citation Indicator (JCI) is a single measurement of the field-normalized citation impact of journals in the Web of Science Core Collection across disciplines. The key words here are that the metric is normalized and cross-disciplinary. JCI: 0.34 SJR: 0.274 SNIP: 0.41 CiteScore™:: 2.8 H-Index: 37

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Cytotoxic Activities of Ergosta-4, 6, 8 (14), 22-tetraen-3-one from the Sclerotia of Grifola umbellata (Pers.) Pilát

Volume 7, Issue 3, 2005, 427 pages
DOI: 10.1615/IntJMedMushrooms.v7.i3.680
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ABSTRACT

Grifola umbellata (also known as Polyporus umbellatus) is a mushroom that is used as a diuretic in Chinese medicine. Herein, we report on the isolation and identification of a cytotoxic compound from the sclerotia of G. umbellata.
For the isolation of the compound, a hexane soluble fraction of the sclerotia of G. umbellata was subjected to column chromatography on silica gel and/or Sephadex LH-20 column eluted with organic solvents. The structure of the isolated compound was elucidated using IR, MS, 1H-, and 13C-NMR spectra, and the structure of the compound was determined as ergosta-4, 6, 8 (14), 22-tetraen-3-one (erogone).
Cytotoxic activities of erogone compared to human cancer cell lines, HT-29 (colon cancer), HeLa 229 (cervix cancer), Hep3B (liver cancer), and AGS (stomach cancer) were compared using the XTT assay kit. Ergone inhibited all cell lines as the dose was increased. In the case of Hep3B and HT-29 cell lines, maximal cytotoxic activities of erogone were achieved at the concentrations of 10 and 15 μ/mL, respectively. However, the cytotoxic activities of erogone compared to HeLa 229 and AGS were much weaker than those of Hep3B and HT-29 cell lines. Values of 50% inhibitory concentrations (IC50) of erogone against Hep3B, HT-29, HeLa 229, and AGS were 5, 7.2, 26.3, and 22 μ/mL, respectively.
Cytotoxic activities of erogone against various tumor cell lines were evaluated in this study for the first time. Therefore, other mushrooms were also examined for the presence of the compound. In the present study, we measured the content of erogone in eight mushrooms—Grifola umbellata, Lentinus edodes (Berk.) Singer, Ganoderma applanatum (Pers.:Wallr.) Pat., Tricholoma matsutake (S.Ito et S.Imai) Singer, Sarcodon aspratus (Berk.) S.Ito, Ramaria botrytis (Pers.) Ricken, Pleurotus eryngii (DC.:Fr.) Quél., and Sparassis crispa (Wulf.)Fr.—and four mycelia—Grifola umbellata, Lentinus edodes, Ganoderma applanatum, and Tricholoma matsutake—using HPLC. The contents of erogone in mushroom and mycelium were in the range of 4.8−29.0 μ/g and 15.5−38.0 μ/g, respectively. Among mushrooms and mycelia tested, the mycelia of Grifola umbellata and Tricholoma matsutake had the highest amounts of erogone (38.0 μ/g).

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