Library Subscription: Guest
Begell Digital Portal Begell Digital Library eBooks Journals References & Proceedings Research Collections
International Journal of Medicinal Mushrooms
IF: 1.423 5-Year IF: 1.525 SJR: 0.433 SNIP: 0.661 CiteScore™: 1.38

ISSN Print: 1521-9437
ISSN Online: 1940-4344

International Journal of Medicinal Mushrooms

DOI: 10.1615/IntJMedMushr.v9.i1.40
pages 29-38

Potential Benefits of Ling Zhi or Reishi Mushroom Ganoderma lucidum (W. Curt.: Fr.) P. Karst. (Aphyllophoromycetideae) to Breast Cancer Patients

Alice W. Chen
Specialty Mushrooms, 1730 Penfield Rd., No.41, Penfield, NY 14526, USA
John Seleen
Mushroom Science Laboratory, JHS Natural Products, P.O. Box 50398, Eugene, OR 97405, USA


We present a model case study of a stage IIIa breast cancer patient adapting to the adjuvant use of Ganoderma lucidum in conjunction with a standard regimen of breast cancer treatments (presurgery ACT chemotherapy, surgery, radiotherapy, and postsurgery chemoprevention). According to the personal account of the authors of this research, G. lucidum triterpene-enriched polysaccharide extract of a new hybrid, Reishi Gano 161, containing 12% β-D-glucan and 6% triterpenes, was beneficial to the patient in numerous ways, such as effective tumor shrinkage, minimal or transient side effects from chemotherapy and radiotherapy, and improvement of the quality of life, compared to the experience of patients who used only conventional cancer treatments. New studies unveiled the molecular mechanism of the antitumor activity of this legendary medicinal mushroom, which appeared to be based on the inhibition of the nuclear transcription factor, NF-kappaB (NF-κB). NF-κB is overexpressed in various cancer cell lines and can serve as a molecular target for the development of more precise chemoprevention and anticancer therapy.

Articles with similar content:

Potential Role of Medicinal Mushrooms in Breast Cancer Treatment: Current Knowledge and Future Perspectives
International Journal of Medicinal Mushrooms, Vol.7, 2005, issue 1&2
Roumyana D. Petrova, Cvetomir M. Denchev, Jamal A. Mahajna
On the Mechanism of Cellular Toxicity in Breast Cancer by Ionizing Radiation and Chemotherapeutic Drugs
Journal of Environmental Pathology, Toxicology and Oncology, Vol.33, 2014, issue 1
Vidhula Ahire, Kaushala Prasad Mishra, G. R. Kulkarni
Venoms Can Be a Boon for Cancer Patients
Forum on Immunopathological Diseases and Therapeutics, Vol.4, 2013, issue 3-4
Sudhir Kumar, Ruchi Jain, Puja Sarkar
The Nature of Apoptosis of Human Breast Cancer Cells Induced by Three Species of Genus Ganoderma P. Karst. (Aphyllophoromycetideae) Crude Extracts
International Journal of Medicinal Mushrooms, Vol.10, 2008, issue 2
Suhaila Mohamed, Abdul Manaf Ali, Chow Chin Tong, Nor Aini B. Umar, Mohamed Mustapha Noordin, Yew Keong Choong
Apoptotic Effect of Taiwanofungus salmoneus (Agaricomycetes) Mycelia and Solid-State Fermented Products on Cancer Cells
International Journal of Medicinal Mushrooms, Vol.19, 2017, issue 9
Jeng-Leun Mau, Yu-Chieh Lin, Rao-Chi Chien