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International Journal of Medicinal Mushrooms
IF: 1.423 5-Year IF: 1.525 SJR: 0.431 SNIP: 0.661 CiteScore™: 1.38

ISSN Print: 1521-9437
ISSN Online: 1940-4344

International Journal of Medicinal Mushrooms

DOI: 10.1615/IntJMedMushr.v9.i1.50
pages 39-46

Adverse Effects of Mycelia and Culture Broth Extracts from Bjerkandera adusta (Willd.: Fr.) P. Karst. and Hypholoma fasciculare (Huds.: Fr.) P. Kumm. on Breast and Prostate Cancer Cells

Ben-Zion Zaidman
Institute of Evolution, University of Haifa, Mount Carmel, Haifa 31905, Israel; and Migal, Galilee Technology Center, Cancer Drug Discovery Program, P.O. Box 831, Kiryat Shmona 11016, Israel
Anna Lutin
Migal, Galilee Technology Center, Cancer Drug Discovery Program, P.O. Box 831, Kiryat Shmona 11016, Israel
Eviatar D. Nevo
Department of Evolutionary and Environmental Biology, Faculty of Natural Sciences, Institute of Evolution, University of Haifa, 199 Abba Khousi Ave., Mt. Carmel, Haifa 3498838, Israel
Jamal A. Mahajna
Migal, Galilee Technology Center, Cancer Drug Discovery Program, Kiryat Shmona; Galilee Institute for Applied Research, Nazareth

ABSTRACT

Bjerkandera adusta (Willd.: Fr.) P. Karst. (Hapalopilaceae) and Hypholoma fasciculare (Huds.: Fr.) P. Kumm. (Strophariaceae) higher Basidiomycetes are known for their exceptionally high concentrations of adsorbable organic halogens. The objective of this study was to test the effect of these secondary metabolites on breast and prostate cancer cells. We report that ethyl acetate mycelia and culture broth extracts from B. adusta and H. fasciculare inhibit breast cancer MDA-kb2 and MCF-7 cells and prostate cancer PC-3, DU 145, and LNCaP cell viability. Furthermore, H. fasciculare culture broth extract decreases both MDA-kb2, MCF-7, PC-3, DU 145, and LNCaP cell proliferation and transcriptional activity of the androgen receptor in dihydrotestosteron-induced MDA-kb2 cells.


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