Library Subscription: Guest
Begell Digital Portal Begell Digital Library eBooks Journals References & Proceedings Research Collections
International Journal of Medicinal Mushrooms
IF: 1.423 5-Year IF: 1.525 SJR: 0.433 SNIP: 0.661 CiteScore™: 1.38

ISSN Print: 1521-9437
ISSN Online: 1940-4344

International Journal of Medicinal Mushrooms

DOI: 10.1615/IntJMedMushr.v14.i3.10
pages 211-239

Submerged Cultivation of Medicinal Mushrooms: Bioprocesses and Products (Review)

Vladimir I. Elisashvili
Animal Husbandry and Feed Production Institute of Agricultural University of Georgia, 240 David Agmashenebeli alley, 0159 Tbilisi, Georgia

ABSTRACT

Medicinal mushrooms belonging to higher Basidiomycetes are an immensely rich yet largely untapped resource of useful, easily accessible, natural compounds with various biological activities that may promote human well-being. The medicinal properties are found in various cellular components and secondary metabolites (polysaccharides, proteins and their complexes, phenolic compounds, polyketides, triterpenoids, steroids, alkaloids, nucleotides, etc.), which have been isolated and identified from the fruiting bodies, culture mycelium, and culture broth of mushrooms. Some of these compounds have cholesterol-lowering, anti-diabetic, antioxidant, antitumor, immunomodulating, antimicrobial, and antiviral activities ready for industrial trials and further commercialization, while others are in various stages of development. Recently, the submerged cultivation of medicinal mushrooms has received a great deal of attention as a promising and reproducible alternative for the efficient production of mushroom mycelium and metabolites. Submerged cultivation of mushrooms has significant industrial potential, but its success on a commercial scale depends on increasing product yields and development of novel production systems that address the problems associated with this technique of mushroom cultivation. In spite of many researchers' efforts for the production of bioactive metabolites by mushrooms, the physiological and engineering aspects of submerged cultures are still far from being thoroughly studied. The vast majority of studies have focused on polysaccharide and ganoderic acid production in submerged cultivation of medicinal mushrooms, and very little has been written so far on the antioxidant and hemagglutinating activity of submerged mushroom cultures. The purpose of this review is to provide an update of the present state of the art and future prospects of submerged cultivation of medicinal mushrooms to produce mycelium and bioactive metabolites, and to make a contribution for the research and development of new pharmaceutical products from mushrooms. A brief overview of the metabolic diversity and bioactive compounds of mushrooms produced by submerged cultures is also given.


Articles with similar content:

Grifola frondosa (Dicks.: Fr.) S.F. Gray (Maitake Mushroom): Medicinal Properties, Active Compounds, and Biotechnological Cultivation
International Journal of Medicinal Mushrooms, Vol.9, 2007, issue 2
Bojana Boh, Marin Berovic
Medicinal Properties of Substances Occurring in Higher Basidiomycetes Mushrooms: Current Perspectives (Review)
International Journal of Medicinal Mushrooms, Vol.1, 1999, issue 1
Solomon P. Wasser, Alexander L. Weis
Sulphur Tuft Culinary-Medicinal Mushroom, Laetiporus sulphureus (Bull.: Fr.) Murrill (Aphyllophoromycetideae): Bioactive Compounds and Pharmaceutical Effects (Review)
International Journal of Medicinal Mushrooms, Vol.11, 2009, issue 2
Natasa Radic, Rade Injac
Current Advances in the Antimicrobial Potential of Species of Genus Ganoderma (Higher Basidiomycetes) against Human Pathogenic Microorganisms (Review)
International Journal of Medicinal Mushrooms, Vol.17, 2015, issue 10
Mahendra K. Rai, Carolina Alves dos Santos, Dipali Nagaonkar, Swapnil Gaikwad
In Vitro Antitumor Activity and Structure Characterization of Ethanol Extracts from Wild and Cultivated Chaga Medicinal Mushroom, Inonotus obliquus (Pers.:Fr.) Pilát (Aphyllophoromycetideae)
International Journal of Medicinal Mushrooms, Vol.13, 2011, issue 2
Xian-Hui Chen, Ting Yin, Rempel B. Curtis, Gong Zhang, Zhan-Hui Lu, Yong Sun, Ji-Hong Jiang