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International Journal of Medicinal Mushrooms

Published 12 issues per year

ISSN Print: 1521-9437

ISSN Online: 1940-4344

The Impact Factor measures the average number of citations received in a particular year by papers published in the journal during the two preceding years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) IF: 1.2 To calculate the five year Impact Factor, citations are counted in 2017 to the previous five years and divided by the source items published in the previous five years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) 5-Year IF: 1.4 The Immediacy Index is the average number of times an article is cited in the year it is published. The journal Immediacy Index indicates how quickly articles in a journal are cited. Immediacy Index: 0.3 The Eigenfactor score, developed by Jevin West and Carl Bergstrom at the University of Washington, is a rating of the total importance of a scientific journal. Journals are rated according to the number of incoming citations, with citations from highly ranked journals weighted to make a larger contribution to the eigenfactor than those from poorly ranked journals. Eigenfactor: 0.00066 The Journal Citation Indicator (JCI) is a single measurement of the field-normalized citation impact of journals in the Web of Science Core Collection across disciplines. The key words here are that the metric is normalized and cross-disciplinary. JCI: 0.34 SJR: 0.274 SNIP: 0.41 CiteScore™:: 2.8 H-Index: 37

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Effect of Agaricus brasiliensis S. Wasser et al. (Agarico-mycetideae) on Murine Diabetic Model C57BL/Ksj-db/db

Volume 8, Issue 2, 2006, pp. 115-128
DOI: 10.1615/IntJMedMushr.v8.i2.30
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ABSTRACT

Agaricus brasiliensis is a medicinal mushroom widely eaten and prescribed in the world. We have recently examined the structure and antitumor activity of polysaccharide fractions of the fruit body and concluded a significant contribution of the highly branched 1,3-beta-glucan moieties to the activity. In the present study, the pharmacological effect of the cold and the hot water extracts (CWE and HWE) on a murine diabetic model C57BL Ksj-db/db was examined from the viewpoints of physiology, immunology, and histology. CWE and HWE were orally administered to db/db mice every day for 28 weeks. Compared to the water administered control group, the body weight, urinary glucose exclusion, urinary pH, blood glucose level, and organs weight were comparable. The number of cells in CWE administered mice was significantly reduced compared to the control and the HWE administered group, and the ratios of T cells versus B cells (CD3/B220) and T cells versus NK cells (CD3/NK1.1) were relatively increased in the CWE administered group. The splenocytes of CWE administered mice produced a higher concentration of IL-6 by Con A stimulation and IFN-γ and IL-6 by LPS stimulation. By megascopic and microscopic examinations of renal sections, the number of the mice having abnormal kidney was 3/5 (control), 2/5 (HWE), and 0/5 (CWE), and suggested the activity of the renal protection in CWE. These facts strongly suggested that the pharmacological action of the cold water extract of A. brasiliensis significantly differ from that of the hot water extract.

CITED BY
  1. Yamanaka Daisuke, Motoi Masuro, Ishibashi Ken-ichi, Miura Noriko N., Adachi Yoshiyuki, Ohno Naohito, Effect ofAgaricus brasiliensis-derived cold water extract on Toll-like receptor 2-dependent cytokine productionin vitro, Immunopharmacology and Immunotoxicology, 34, 4, 2012. Crossref

  2. Han Chien-Kuo, Chiang Hsin-Chieh, Lin Chien-Yin, Tang Chih-Hsin, Lee Hsinyu, Huang Ding-Ding, Zeng Yu-Ru, Chuang Tsai-Ni, Huang Yuan-Li, Comparison of Immunomodulatory and Anticancer Activities in Different Strains of Tremella fuciformis Berk, The American Journal of Chinese Medicine, 43, 08, 2015. Crossref

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