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International Journal of Medicinal Mushrooms

Published 12 issues per year

ISSN Print: 1521-9437

ISSN Online: 1940-4344

The Impact Factor measures the average number of citations received in a particular year by papers published in the journal during the two preceding years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) IF: 1.2 To calculate the five year Impact Factor, citations are counted in 2017 to the previous five years and divided by the source items published in the previous five years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) 5-Year IF: 1.4 The Immediacy Index is the average number of times an article is cited in the year it is published. The journal Immediacy Index indicates how quickly articles in a journal are cited. Immediacy Index: 0.3 The Eigenfactor score, developed by Jevin West and Carl Bergstrom at the University of Washington, is a rating of the total importance of a scientific journal. Journals are rated according to the number of incoming citations, with citations from highly ranked journals weighted to make a larger contribution to the eigenfactor than those from poorly ranked journals. Eigenfactor: 0.00066 The Journal Citation Indicator (JCI) is a single measurement of the field-normalized citation impact of journals in the Web of Science Core Collection across disciplines. The key words here are that the metric is normalized and cross-disciplinary. JCI: 0.34 SJR: 0.274 SNIP: 0.41 CiteScore™:: 2.8 H-Index: 37

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In Vitro Anti-proliferative Effects on NB4 Human Leukemia Cells and Physicochemical Screening of Pleurotus sp. (Higher Basidiomycetes) Mycelia from Cuba

Volume 16, Issue 3, 2014, pp. 239-245
DOI: 10.1615/IntJMedMushr.v16.i3.40
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ABSTRACT

This study examined the phytochemical profile and the in vitro anti-proliferative effects of a hot water mycelial extract from the edible mushroom Pleurotus sp. on NB4 human leukemia cells. Flow-cytometry analyses were used to measure cell viability, cell cycle, and apoptosis in cells incubated 24 h with the extract at doses of 100 and 200 µg/mL. Pleurotus sp. extract reduced cell viability, particularly at the concentration of 200 µg/mL to 82% compared to control cells, and induced apoptosis demonstrated by an increase in the number of annexin V-FITC+ cells (25% at 200 µg/mL). The NB4 cells were arrested in the G2/M phase thus supporting a cell-cycle dependent anticancer mechanism. Although carbohydrates (76.8%, w/w) appear to be the most important antitumor compound, secondary metabolites-like phenolics would also contribute to the anti-proliferative activity. The results indicate that Pleurotus sp. mycelia obtained by submerged fermentation may be an interesting renewable resource for developing functional foods and new antitumor therapeutic agents.

CITED BY
  1. Llauradó G., Morris H.J., Tamayo V., Lebeque Y., Beltrán Y., Marcos J., Moukha S., Creppy E.E., Bermúdez R.C., Haematopoiesis radioprotection in Balb/c mice by an aqueous mycelium extract from the BasidiomycetePleurotus ostreatusmushroom, Natural Product Research, 29, 16, 2015. Crossref

  2. Llauradó Gabriel, Morris Humberto J., Ferrera Leodán, Camacho Miladis, Castán Leniher, Lebeque Yamila, Beltrán Yaixa, Cos Paul, Bermúdez Rosa C., In-vitro antimicrobial activity and complement/macrophage stimulating effects of a hot-water extract from mycelium of the oyster mushroom Pleurotus sp., Innovative Food Science & Emerging Technologies, 30, 2015. Crossref

  3. Morris Humberto J., Llauradó Gabriel, Beltrán Yaixa, Lebeque Yamila, Bermúdez Rosa C., García Nora, Gaime-Perraud Isabelle, Moukha Serge, The Use of Mushrooms in the Development of Functional Foods, Drugs, and Nutraceuticals, in Wild Plants, Mushrooms and Nuts, 2016. Crossref

  4. Nowacka-Jechalke Natalia, Olech Marta, Nowak Renata, Mushroom Polyphenols as Chemopreventive Agents, in Polyphenols: Prevention and Treatment of Human Disease, 2018. Crossref

  5. Llauradó Maury Gabriel, Morris-Quevedo Humberto J., Heykers Annick, Lanckacker Ellen, Cappoen Davie, Delputte Peter, Vanden Berghe Wim, Salgueiro Zelene, Cos Paul, Differential Induction Pattern Towards Classically Activated Macrophages in Response to an Immunomodulatory Extract from Pleurotus ostreatus Mycelium, Journal of Fungi, 7, 3, 2021. Crossref

  6. Vieira Gomes Débora Cássia, de Alencar Marcus Vinícius Oliveira Barros, dos Reis Antonielly Campinho, de Lima Rosália Maria Torres, de Oliveira Santos José Victor, da Mata Ana Maria Oliveira Ferreira, Soares Dias Ana Carolina, da Costa Joaquim Soares, de Medeiros Maria das Graças Freire, Paz Márcia Fernanda Correia Jardim, Gayoso e Almendra Ibiapina Moreno Lina Clara, Castro e Sousa João Marcelo de, Islam Muhammad Torequl, Melo Cavalcante Ana Amélia de Carvalho, Antioxidant, anti-inflammatory and cytotoxic/antitumoral bioactives from the phylum Basidiomycota and their possible mechanisms of action, Biomedicine & Pharmacotherapy, 112, 2019. Crossref

  7. Nowakowski Patryk, Markiewicz-Żukowska Renata, Bielecka Joanna, Mielcarek Konrad, Grabia Monika, Socha Katarzyna, Treasures from the forest: Evaluation of mushroom extracts as anti-cancer agents, Biomedicine & Pharmacotherapy, 143, 2021. Crossref

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