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International Journal of Medicinal Mushrooms
CiteScore™: 1.38 IF: 1.211 5-Year IF: 1.394 SNIP: 0.661 SJR: 0.433

ISSN Print: 1521-9437
ISSN Online: 1940-4344

International Journal of Medicinal Mushrooms

DOI: 10.1615/IntJMedMushrooms.v19.i3.10
pages 191-202

An Overview of Culinary and Medicinal Mushrooms in Neurodegeneration and Neurotrauma Research

Kah-Hui Wong
Department of Anatomy, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia; Mushroom Research Centre, Faculty of Science, University of Malaya, Kuala Lumpur, Malaysia
Chai-Chee Ng
Mushroom Research Centre, Faculty of Science, University of Malaya, Kuala Lumpur, Malaysia; Institute of Biological Sciences, Faculty of Science, University of Malaya, Kuala Lumpur, Malaysia
Gowri Kanagasabapathy
Mushroom Research Centre, Faculty of Science, University of Malaya, Kuala Lumpur, Malaysia
Yoon-Yen Yow
Department of Biological Sciences, School of Science and Technology, Sunway University, Bandar Sunway, Selangor Darul Ehsan, Malaysia
Vikineswary Sabaratnam
Mushroom Research Centre, University of Malaya, Kuala Lumpur, Malaysia; Institute of Biological Sciences, Faculty of Science, University of Malaya, Kuala Lumpur, Malaysia

ABSTRACT

Culinary and medicinal mushrooms have been appreciated since prehistoric times as valuable resources for food and medicine. Edible mushrooms represent an untapped source of nutraceuticals and valuable palatable food. Long considered tonics, they are now treasured as functional foods that can improve human health and quality of life. Numerous studies have provided insights into the neuroprotective effects of edible mushrooms, which are attributed to their antioxidant, antineuroinflammatory, and cholinesterase inhibitory properties, and their ability to prevent neuronal death. Here we review the recent literature on the role of culinary and medicinal mushrooms in the management of neurodegenerative diseases and neurotrauma. We highlight some of the molecular mechanisms for how these alternative medicines provide health benefits that could help us to harness their neuroprotective effects.