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International Journal of Medicinal Mushrooms
IF: 1.423 5-Year IF: 1.525 SJR: 0.431 SNIP: 0.661 CiteScore™: 1.38

ISSN Print: 1521-9437
ISSN Online: 1940-4344

International Journal of Medicinal Mushrooms

DOI: 10.1615/IntJMedMushrooms.2019030638
pages 493-502

Taking Ingredients as an Entry Point to Explore the Relationship between the Shaggy Ink Cap Medicinal Mushroom, Coprinus comatus (Agaricomycetes), and Diabetes Mellitus (Review)

Hui Cao
School of Pharmacy, Shandong University of Traditional Chinese Medicine, Jinan, P.R. China
Shiyuan Wang
School of Pharmacy, Shandong University of Traditional Chinese Medicine, Jinan, P.R. China
Xiaowei Cui
School of Pharmacy, Shandong University of Traditional Chinese Medicine, Jinan, P.R. China
Hong Guo
School of Pharmacy, Shandong University of Traditional Chinese Medicine, Jinan, P.R. China
Xiaozhi Xi
School of Pharmacy, Shandong University of Traditional Chinese Medicine, Jinan, P.R. China
Fangxue Xu
School of Pharmacy, Shandong University of Traditional Chinese Medicine, Jinan, P.R. China
Yujuan Li
School of Pharmacy, Shandong University of Traditional Chinese Medicine, Jinan, P.R. China
Mengmeng Zheng
School of Pharmacy, Shandong University of Traditional Chinese Medicine, Jinan, P.R. China
Chunchao Han
School of Pharmacy, Shandong University of Traditional Chinese Medicine, Jinan, People's Republic of China

ABSTRACT

Diabetes mellitus (DM) is a common endocrine and metabolic disease caused by protein and fat metabolism disorders as the main clinical manifestation due to the relative or absolute deficiency of insulin secretion in the body. Despite significant prevention and treatment efforts, the number of people with DM is still increasing. A safe and effective resource to prevent and treat DM is urgently needed. In recent years, many reports have indicated that medicinal mushrooms have a hypoglycemic effect. Among them, Coprinus comatus has great potential for development as a hypoglycemic drug or food; it is an emerging medicinal and edible fungus with a variety of nutrients (polysaccharides, unsaturated fatty acids, dietary fibers, vitamins, trace elements, amino acids, etc.). These ingredients have been closely linked to the hypoglycemic effects of C. comatus, possibly by increasing insulin release, protecting islet cells from invasion, enhancing antioxidant activity, regulating metabolic pathways, and reducing inflammation. This review preliminarily summarizes the hypoglycemic effect of C. comatus by introducing the ingredients it contains, which can provide theoretical support for the development of C. comatus as a potential hypoglycemic resource.


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