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International Journal of Medicinal Mushrooms

Published 12 issues per year

ISSN Print: 1521-9437

ISSN Online: 1940-4344

The Impact Factor measures the average number of citations received in a particular year by papers published in the journal during the two preceding years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) IF: 1.2 To calculate the five year Impact Factor, citations are counted in 2017 to the previous five years and divided by the source items published in the previous five years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) 5-Year IF: 1.4 The Immediacy Index is the average number of times an article is cited in the year it is published. The journal Immediacy Index indicates how quickly articles in a journal are cited. Immediacy Index: 0.3 The Eigenfactor score, developed by Jevin West and Carl Bergstrom at the University of Washington, is a rating of the total importance of a scientific journal. Journals are rated according to the number of incoming citations, with citations from highly ranked journals weighted to make a larger contribution to the eigenfactor than those from poorly ranked journals. Eigenfactor: 0.00066 The Journal Citation Indicator (JCI) is a single measurement of the field-normalized citation impact of journals in the Web of Science Core Collection across disciplines. The key words here are that the metric is normalized and cross-disciplinary. JCI: 0.34 SJR: 0.274 SNIP: 0.41 CiteScore™:: 2.8 H-Index: 37

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Antitumor Effects of Extract of the Oak Bracket Medicinal Mushroom, Phellinus baumii (Agaricomycetes), on Human Melanoma Cells A375 In Vitro and In Vivo

Volume 22, Issue 2, 2020, pp. 197-209
DOI: 10.1615/IntJMedMushrooms.2020033687
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ABSTRACT

Melanoma is among the most aggressive and treatment-resistant human cancers. Phellinus baumii, a famous medicinal mushroom, has been used to treat different diseases, including cancer, in China and other east Asian countries. The purpose of this research was to explore its anticancer effects against melanoma, and the mechanisms that might be involved. CCK-8 assay exhibited that extracts of Ph. baumii (EPB) strongly inhibited cell viability of A375 melanoma cancer cell. Typical morphological changes of cell apoptosis were observed in EPB-treated A375 cells in Hoechst staining assay. Flow cytometry analysis indicated that EPB significantly induced A375 cells apoptosis and the cell cycle was disrupted in S phase. EPB increased the expression of Bax, and decreased Bcl-2 in A375 cells. EPB remarkably caused mitochondrial membrane potential collapse and induced a mitochondrial-dependent apoptosis in A375 cells evidenced by caspase-3 activation, followed by PARP cleavage. More importantly, EPB has shown a strong inhibitory effect on the migration and aggression of the A375 cells through the healing of the wound and transwell assay. In vivo, EPB was also found to strongly inhibit the growth of tumors in BALB/c nude mice. Our results indicated that Ph. baumii might be a natural therapeutic product for aggressive melanoma because it could induce apoptosis and inhibit metastasis in A375 cells.

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CITED BY
  1. Yang Yue, He Ping-Ya, Zhang Yi, Li Ning, Natural Products Targeting the Mitochondria in Cancers, Molecules, 26, 1, 2020. Crossref

  2. Yu Taihen, Zhong Shi, Sun Yuqing, Sun Haiyan, Chen Weiguo, Li Yougui, Zhu Jianxun, Lu Longxi, Huo Jinxi, Aqueous extracts of Sanghuangporus vaninii induce S‑phase arrest and apoptosis in human melanoma A375 cells, Oncology Letters, 22, 2, 2021. Crossref

  3. He Ping-Ya, Hou Yu-Hao, Yang Yue, Li Ning, The anticancer effect of extract of medicinal mushroom Sanghuangprous vaninii against human cervical cancer cell via endoplasmic reticulum stress-mitochondrial apoptotic pathway, Journal of Ethnopharmacology, 279, 2021. Crossref

  4. Kour Harpreet, Kour Satwinder, Sharma Yashpal, Singh Shaveta, Sharma Isha, Kour Divjot, Yadav Ajar Nath, Bioprospecting of Industrially Important Mushrooms, in Industrially Important Fungi for Sustainable Development, 2021. Crossref

  5. Jiang Wenlai, Zhang Xinyi, Liu Ping, Zhang Yu, Song Wenliang, Yu Deng-Guang, Lu Xuhua, Electrospun healthcare nanofibers from medicinal liquor of Phellinus igniarius, Advanced Composites and Hybrid Materials, 2022. Crossref

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