Published 12 issues per year
ISSN Print: 1521-9437
ISSN Online: 1940-4344
Indexed in
Comparison of Some Metabolites Among Cultured Mycelia of Medicinal Fungus, Ophiocordyceps sinensis (Ascomycetes) from Different Geographical Regions
ABSTRACT
Ophiocordyceps sinensis, also named Dong Chong Xia Cao, is one of the best-known Chinese medical fungus, with great benefits to human health and huge economical values. In the present study, cultured mycelia were obtained from submerged cultures with 18 authentic and representative strains from different origins on the Tibetan plateau. The contents of the main metabolites, including adenosine, uridine, guanosine, cordycepin, and D-mannitol, were then determined. There was no obvious trend in the amount of nucleosides between the cultured O. sinensis mycelia and natural products. Among the tested nucleosides, uridine showed the highest concentration. Cordycepin has been confirmed in submerged cultured mycelia. Natural products have a significantly higher content of D-mannitol compared with the submerged cultured mycelia. Based on the content of nucleosides and D-mannitol, hierarchical clustering analysis was performed. The tested samples were divided into two main clusters for cultured mycelia and natural products, respectively. The cultured mycelia of strains from different regions did not group together, suggesting that sample diversity had a greater effect on metabolite content than did the geographical origin. The results also suggested that strain selection is important when O. sinensis is used to manufacture health foods.
-
Yang Tao, Guo Mingmin, Yang Huaijun, Guo Suping, Dong Caihong, The blue-light receptor CmWC-1 mediates fruit body development and secondary metabolism in Cordyceps militaris, Applied Microbiology and Biotechnology, 100, 2, 2016. Crossref
-
Zhang Jianshuang, Zhong Xin, Li Shaosong, Zhang Guren, Liu Xin, Metabolic characterization of natural and cultured Ophicordyceps sinensis from different origins by 1H NMR spectroscopy, Journal of Pharmaceutical and Biomedical Analysis, 115, 2015. Crossref
-
Lo Hui-Chen, Hsieh Chienyan, Lin Fang-Yi, Hsu Tai-Hao, A Systematic Review of the Mysterious Caterpillar Fungus Ophiocordyceps sinensis in DongChongXiaCao (冬蟲夏草 Dōng Chóng Xià Cǎo) and Related Bioactive Ingredients, Journal of Traditional and Complementary Medicine, 3, 1, 2013. Crossref
-
Wang Fen, Song Xinhua, Dong Xiaoming, Zhang Jiaojiao, Dong Caihong, DASH-type cryptochromes regulate fruiting body development and secondary metabolism differently than CmWC-1 in the fungus Cordyceps militaris, Applied Microbiology and Biotechnology, 101, 11, 2017. Crossref
-
Jin Jian, Zhong Can, Qin You, Cai Yuan, Zhen Lanping, Shen Bingbing, Chen Lin, Wan Dan, Qin Yuhui, Zhang Shuihan, A new cordycepin-producing caterpillar fungus Ophiocordyceps xuefengensis with artificial infection to the host, cultivation of mycelia and stromata, FEMS Microbiology Letters, 364, 20, 2017. Crossref
-
Wang Fen, Liu Qing, Zhang Jiaojiao, Liu Kuanbo, Li Kuan, Liu Guijun, Dong Caihong, Comparative Transcriptome Analysis Between a Spontaneous Albino Mutant and Its Sibling Strain of Cordyceps militaris in Response to Light Stress, Frontiers in Microbiology, 9, 2018. Crossref
-
Saki Neslihan, Akin Mustafa, Alici Esma H., Arabaci Gulnur, Partial Purification and Characterization of Polyphenol Oxidase from the Wild Edible Mushroom Lepiota Procera Using Three-Phase Partitioning, International Journal of Food Engineering, 14, 9-10, 2018. Crossref
-
Zhang Jiaojiao, Wang Fen, Yang Ying, Wang Ying, Dong Caihong, CmVVD is involved in fruiting body development and carotenoid production and the transcriptional linkage among three blue‐light receptors in edible fungusCordyceps militaris, Environmental Microbiology, 22, 1, 2020. Crossref
-
Zhou Yujue, Wang Min, Zhang Hui, Huang Zhuo, Ma Jun, Šiler Branislav T., Comparative study of the composition of cultivated, naturally grown Cordyceps sinensis, and stiff worms across different sampling years, PLOS ONE, 14, 12, 2019. Crossref
-
Xu Zixian, Li Shan, Chen Lingling, Zhu Yunguo, Xuan Lingyan, Cheng Zhou, Effects of fungus–host associations on nucleoside differences among Ophiocordyceps sinensis populations on the Qinghai–Tibet Plateau of China, Archives of Microbiology, 202, 8, 2020. Crossref
-
Guo Yanlong, Zhao Zefang, Li Xin, Moderate warming will expand the suitable habitat of Ophiocordyceps sinensis and expand the area of O. sinensis with high adenosine content, Science of The Total Environment, 787, 2021. Crossref